Adipose tissue is a highly heterogeneous endocrine organ. The heterogeneity among
different anatomical depots stems from their intrinsic differences in cellular and physiological …

Kawai M, de Paula FJA, Rosen CJ (Osaka Medical Center and Research Institute for
Maternal and Child Health, Izumi, Osaka, Japan; University of São Paulo, Ribeirão Preto …

Autism spectrum disorders (ASD) are common, complex and heterogeneous
neurodevelopmental disorders. Cellular and molecular mechanisms responsible for ASD …

WNT signaling controls many biological processes including cell differentiation in
metazoans. However, how WNT reprograms cell identity is not well understood. We have …

Wnt/β-catenin/TCF signaling stimulates bone formation and suppresses adipogenesis. The
hallmarks of skeletal involution with age, on the other hand, are decreased bone formation …

Bone marrow (BM) microenvironment represents an important compartment of bone that
regulates bone homeostasis and the balance between bone formation and bone resorption …

The Wnt coreceptors Lrp5 and Lrp6 are essential for normal postnatal bone accrual and
osteoblast function. In this study, we identify a previously unrecognized skeletal function …

WISP1 (Wnt1-inducible signaling pathway protein-1, also known as CCN4) is a member of
the secreted extracellular matrix–associated proteins of the CCN family and a target gene of …

Diabetes is a common disease affecting majority of populations worldwide. Since 1980,
there has been an increase in the number of people diagnosed as prediabetic and diabetic …

Abstract PI3K/AKT is one of the key pathways that regulate cell behaviors including
apoptosis, proliferation, and differentiation. Although previous studies have demonstrated …