Major recent advances and previous data have led to a plausible model of how key proteins
mediate neurotransmitter release. In this model, the soluble N-ethylmaleimide-sensitive …

Accumulating data from the clinical research support that the core Alzheimer's disease (AD)
cerebrospinal fluid (CSF) biomarkers amyloid‐β (Aβ42), total tau (T‐tau), and …

INTRODUCTION Protein-protein interactions play critical roles in biology, but the structures
of many eukaryotic protein complexes are unknown, and there are likely many interactions …

Here we conducted a large-scale genetic association analysis of educational attainment in a
sample of approximately 1.1 million individuals and identify 1,271 independent genome …

Soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) are a
family of small conserved eukaryotic proteins that mediate membrane fusion between …

Abstract Alzheimer's disease (AD), being the number one in terms of dementia burden, is an
insidious age-related neurodegenerative disease and is presently considered a global …

Autophagy, an important catabolic pathway implicated in a broad spectrum of human
diseases, begins by forming double membrane autophagosomes that engulf cytosolic cargo …

The etiology of migraine pain involves sensitized meningeal afferents that densely innervate
the dural vasculature. These afferents, with their cell bodies located in the trigeminal …

Membrane fusion is a key process in all living organisms that contributes to a variety of
biological processes including viral infection, cell fertilization, as well as intracellular …

ATPases associated with diverse cellular activities (AAA+ proteins) are a superfamily of
proteins found throughout all domains of life. The hallmark of this family is a conserved …