Inhibitors of DNA glycosylases as prospective drugs

GV Mechetin, AV Endutkin, EA Diatlova… - International Journal of …, 2020 - mdpi.com
DNA glycosylases are enzymes that initiate the base excision repair pathway, a major
biochemical process that protects the genomes of all living organisms from intrinsically and …

GO system, a DNA repair pathway to cope with oxidative damage

AV Endutkin, DO Zharkov - Molecular Biology, 2021 - Springer
The GO system is part of the DNA base excision repair pathway and is required for the error-
free repair of 8-oxoguanine (oxoG), one of the most common oxidative DNA lesions. Due to …

Functionalization of mesoporous silica with a GA-Mismatched dsDNA chain for efficient identification and selective capturing of the MutY protein

J Sun, J Wang, X Chen - ACS Applied Materials & Interfaces, 2023 - ACS Publications
MUTYH adenine DNA glycosylase and its homologous protein (collectively MutY) are typical
DNA glycosylases with a [4Fe4S] cluster and a helix–hairpin–helix (HhH) motif in its …

The polyanions heparin and suramin impede binding of free adenine to a DNA glycosylase from C. pseudotuberculosis

RJ Eberle, MA Coronado, RS Peinado… - International journal of …, 2019 - Elsevier
Currently no effective treatment is available to combat infections caused by
Corynebacterium pseudotuberculosis in livestock. Survival of this Gram-positive bacterium …

UvrB protein of Corynebacterium pseudotuberculosis complements the phenotype of knockout Escherichia coli and recognizes DNA damage caused by UV radiation …

BCT Castro, RC de Faria, BF Faria, V Azevedo… - Gene, 2018 - Elsevier
In prokaryotic cells, the UvrB protein plays a central role in nucleotide excision repair, which
is involved in the recognition of bulky DNA lesions generated by chemical or physical …