Pragmatic coarse-graining of proteins: models and applications
The molecular details involved in the folding, dynamics, organization, and interaction of
proteins with other molecules are often difficult to assess by experimental techniques …
proteins with other molecules are often difficult to assess by experimental techniques …
[HTML][HTML] Coping with stress: how bacteria fine-tune protein synthesis and protein transport
Maintaining a functional proteome under different environmental conditions is challenging
for every organism, in particular for unicellular organisms, such as bacteria. In order to cope …
for every organism, in particular for unicellular organisms, such as bacteria. In order to cope …
[HTML][HTML] The dynamic SecYEG translocon
J Oswald, R Njenga, A Natriashvili… - Frontiers in Molecular …, 2021 - frontiersin.org
The spatial and temporal coordination of protein transport is an essential cornerstone of the
bacterial adaptation to different environmental conditions. By adjusting the protein …
bacterial adaptation to different environmental conditions. By adjusting the protein …
Genetic, cellular and structural characterization of the membrane potential-dependent cell-penetrating peptide translocation pore
E Trofimenko, G Grasso, M Heulot, N Chevalier… - Elife, 2021 - elifesciences.org
Cell-penetrating peptides (CPPs) allow intracellular delivery of bioactive cargo molecules.
The mechanisms allowing CPPs to enter cells are ill-defined. Using a CRISPR/Cas9-based …
The mechanisms allowing CPPs to enter cells are ill-defined. Using a CRISPR/Cas9-based …
[HTML][HTML] Cellular dynamics of the SecA ATPase at the single molecule level
AB Seinen, D Spakman, AM van Oijen… - Scientific Reports, 2021 - nature.com
Abstract In bacteria, the SecA ATPase provides the driving force for protein secretion via the
SecYEG translocon. While the dynamic interplay between SecA and SecYEG in …
SecYEG translocon. While the dynamic interplay between SecA and SecYEG in …
[HTML][HTML] Cardiolipin is required in vivo for the stability of bacterial translocon and optimal membrane protein translocation and insertion
S Ryabichko, VM Ferreira, H Vitrac, R Kiyamova… - Scientific reports, 2020 - nature.com
Translocation of preproteins across the Escherichia coli inner membrane requires anionic
lipids by virtue of their negative head-group charge either in vivo or in situ. However …
lipids by virtue of their negative head-group charge either in vivo or in situ. However …
[HTML][HTML] Characterizing the role of phosphatidylglycerol-phosphate phosphatases in Acinetobacter baumannii cell envelope biogenesis and antibiotic resistance
M Zang, A Ascari, FG Adams, S Alquethamy… - The Cell Surface, 2023 - Elsevier
The dissemination of multi-drug resistant Acinetobacter baumannii threatens global
healthcare systems and necessitates the development of novel therapeutic options. The …
healthcare systems and necessitates the development of novel therapeutic options. The …
[HTML][HTML] Phospholipid dependency of membrane protein insertion by the Sec translocon
MJ den Uijl, AJM Driessen - Biochimica et Biophysica Acta (BBA) …, 2024 - Elsevier
Membrane protein insertion into and translocation across the bacterial cytoplasmic
membrane are essential processes facilitated by the Sec translocon. Membrane insertion …
membrane are essential processes facilitated by the Sec translocon. Membrane insertion …
Unsaturated fatty acids augment protein transport via the SecA: SecYEG translocon
M Kamel, M Löwe, S Schott‐Verdugo… - The FEBS …, 2022 - Wiley Online Library
The translocon SecYEG and the associated ATPase SecA form the primary protein secretion
system in the cytoplasmic membrane of bacteria. The secretion is essentially dependent on …
system in the cytoplasmic membrane of bacteria. The secretion is essentially dependent on …
Cooperativity in regulation of membrane protein function: phenomenological analysis of the effects of pH and phospholipids
G Zerbetto De Palma, AA Recoulat Angelini, V Vitali… - Biophysical …, 2023 - Springer
Interaction between membrane proteins and ligands plays a key role in governing a wide
spectrum of cellular processes. These interactions can provide a cooperative-type regulation …
spectrum of cellular processes. These interactions can provide a cooperative-type regulation …