The molecular details involved in the folding, dynamics, organization, and interaction of
proteins with other molecules are often difficult to assess by experimental techniques …

Maintaining a functional proteome under different environmental conditions is challenging
for every organism, in particular for unicellular organisms, such as bacteria. In order to cope …

The spatial and temporal coordination of protein transport is an essential cornerstone of the
bacterial adaptation to different environmental conditions. By adjusting the protein …

Cell-penetrating peptides (CPPs) allow intracellular delivery of bioactive cargo molecules.
The mechanisms allowing CPPs to enter cells are ill-defined. Using a CRISPR/Cas9-based …

Abstract In bacteria, the SecA ATPase provides the driving force for protein secretion via the
SecYEG translocon. While the dynamic interplay between SecA and SecYEG in …

Translocation of preproteins across the Escherichia coli inner membrane requires anionic
lipids by virtue of their negative head-group charge either in vivo or in situ. However …

The dissemination of multi-drug resistant Acinetobacter baumannii threatens global
healthcare systems and necessitates the development of novel therapeutic options. The …

Membrane protein insertion into and translocation across the bacterial cytoplasmic
membrane are essential processes facilitated by the Sec translocon. Membrane insertion …

The translocon SecYEG and the associated ATPase SecA form the primary protein secretion
system in the cytoplasmic membrane of bacteria. The secretion is essentially dependent on …

Interaction between membrane proteins and ligands plays a key role in governing a wide
spectrum of cellular processes. These interactions can provide a cooperative-type regulation …