• The specific situation of the patient. Unless otherwise provided for by national regulations,
off-label use of medication should be limited to situations where it is in the patient's interest …

The metabolic syndrome (MetS) is a multiplex modifiable risk factor for cardiovascular
disease, type 2 diabetes mellitus and other health outcomes, and is a major challenge to …

Increases in calorie consumption and sedentary lifestyles are fuelling a global pandemic of
cardiometabolic diseases, including coronary artery disease, diabetes mellitus …

The global prevalence of metabolic diseases such as type 2 diabetes mellitus,
steatohepatitis, myocardial infarction, and stroke has increased dramatically over the past …

Importance Aging is associated with a decline in mitochondrial function and reduced
exercise capacity. Urolithin A is a natural gut microbiome–derived food metabolite that has …

BACKGROUND Ceramides are sphingolipids that play causative roles in diabetes and heart
disease, with their serum levels measured clinically as biomarkers of cardiovascular disease …

Lipids are vital biological molecules and play multiple roles in cellular function of
mammalian organisms such as cellular membrane anchoring, signal transduction, material …

The human plasma lipidome captures risk for cardiometabolic diseases. To discover new
lipid-associated variants and understand the link between lipid species and cardiometabolic …

Growing evidence suggests that ceramides play an important role in the development of
atherosclerotic and valvular heart disease. Ceramides are biologically active sphingolipids …

Prospective observational studies support the use of long-chain omega-3 polyunsaturated
fatty acids (PUFAs) in the primary prevention of atherosclerotic cardiovascular disease; …