The mechanism and consequences of SARS-CoV-2 spike-mediated fusion and syncytia formation

MM Rajah, A Bernier, J Buchrieser… - Journal of molecular …, 2022 - Elsevier
Syncytia are formed when individual cells fuse. SARS-CoV-2 induces syncytia when the
viral spike (S) protein on the surface of an infected cell interacts with receptors on …

SARS-CoV-2 and the host cell: a tale of interactions

M Pizzato, C Baraldi, G Boscato Sopetto… - Frontiers in …, 2022 - frontiersin.org
The ability of a virus to spread between individuals, its replication capacity and the clinical
course of the infection are macroscopic consequences of a multifaceted molecular …

Syncytia formation during SARS-CoV-2 lung infection: a disastrous unity to eliminate lymphocytes

L Lin, Q Li, Y Wang, Y Shi - Cell Death & Differentiation, 2021 - nature.com
Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) infection, has become a major threat to the global public health …

SARS-CoV-2: a master of immune evasion

A Rubio-Casillas, EM Redwan, VN Uversky - Biomedicines, 2022 - mdpi.com
Viruses and their hosts have coevolved for a long time. This coevolution places both the
pathogen and the human immune system under selective pressure; on the one hand, the …

Sensing of cytoplasmic chromatin by cGAS activates innate immune response in SARS-CoV-2 infection

Z Zhou, X Zhang, X Lei, X Xiao, T Jiao, R Ma… - … and Targeted Therapy, 2021 - nature.com
The global coronavirus disease 2019 (COVID-19) pandemic is caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), a positive-sense RNA virus. How the …

HIV–host cell interactions

SK Masenga, BC Mweene, E Luwaya, L Muchaili… - Cells, 2023 - mdpi.com
The development of antiretroviral drugs (ARVs) was a great milestone in the management of
HIV infection. ARVs suppress viral activity in the host cell, thus minimizing injury to the cells …

Spike protein mediated membrane fusion during SARS‐CoV‐2 infection

X Li, H Yuan, X Li, H Wang - Journal of Medical Virology, 2023 - Wiley Online Library
The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2)
has posed a serious threat to public health and has quickly become a global concern. The …

[HTML][HTML] Immune evasion of SARS-CoV-2 from interferon antiviral system

YQ Min, M Huang, X Sun, F Deng, H Wang… - Computational and …, 2021 - Elsevier
The on-going pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to unprecedented medical and …

Imatinib inhibits SARS-CoV-2 infection by an off-target-mechanism

R Strobelt, J Adler, N Paran, Y Yahalom-Ronen… - Scientific reports, 2022 - nature.com
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causal agent of
the COVID-19 pandemic. More than 274 million individuals have suffered from COVID-19 …

HIV-1 and HTLV-1 transmission modes: Mechanisms and importance for virus spread

S Kalinichenko, D Komkov, D Mazurov - Viruses, 2022 - mdpi.com
So far, only two retroviruses, human immunodeficiency virus (HIV)(type 1 and 2) and human
T-cell lymphotropic virus type 1 (HTLV-1), have been recognized as pathogenic for humans …