Prevalence of small base-pairing RNAs derived from diverse genomic loci

PP Adams, G Storz - Biochimica Et Biophysica Acta (BBA)-Gene …, 2020 - Elsevier
Small RNAs (sRNAs) that act by base-pairing have been shown to play important roles in
fine-tuning the levels and translation of their target transcripts across a variety of model and …

Gene regulation and transcriptomics

DS Samuels, MC Lybecker, XF Yang, Z Ouyang… - Current issues in …, 2021 - mdpi.com
Borrelia (Borreliella) burgdorferi, along with closely related species, is the etiologic agent of
Lyme disease. The spirochete subsists in an enzootic cycle that encompasses acquisition …

Coupled induction of prophage and virulence factors during tick transmission of the Lyme disease spirochete

J Wachter, B Cheff, C Hillman, V Carracoi… - Nature …, 2023 - nature.com
The alternative sigma factor RpoS plays a central role in the critical host-adaptive response
of the Lyme disease spirochete, Borrelia burgdorferi. We previously identified bbd18 as a …

Small RNAs as fundamental players in the transference of information during bacterial infectious diseases

JJ González Plaza - Frontiers in Molecular Biosciences, 2020 - frontiersin.org
Communication shapes life on Earth. Transference of information has played a paramount
role on the evolution of all living or extinct organisms since the appearance of life. Success …

Genome-wide screen identifies novel genes required for Borrelia burgdorferi survival in its Ixodes tick vector

JP Phelan, A Kern, ME Ramsey, ME Lundt… - PLoS …, 2019 - journals.plos.org
Borrelia burgdorferi, the causative agent of Lyme disease in humans, is maintained in a
complex biphasic life cycle, which alternates between tick and vertebrate hosts. To …

[HTML][HTML] Evolutionary ecology of lyme borrelia

KR O'Keeffe, ZJ Oppler, D Brisson - Infection, Genetics and Evolution, 2020 - Elsevier
The bacterial genus, Borrelia, is comprised of vector-borne spirochete species that infect
and are transmitted from multiple host species. Some Borrelia species cause highly …

Regulation of gene and protein expression in the Lyme disease spirochete

B Stevenson, J Seshu - Spirochete Biology: The Post Genomic Era, 2018 - Springer
The infectious cycle of Borrelia burgdorferi necessitates persistent infection of both
vertebrates and ticks, and efficient means of transmission between those two very different …

Hitchhiker's Guide to Borrelia burgdorferi

JS Bourgeois, LT Hu - Journal of Bacteriology, 2024 - journals.asm.org
ABSTRACT Don't Panic. In the nearly 50 years since the discovery of Lyme disease, Borrelia
burgdorferi has emerged as an unlikely workhorse of microbiology. Interest in studying host …

Novel cell receptor system of eukaryotes formed by previously unknown nucleic acid-based receptors

V Tetz, G Tetz - Receptors, 2022 - mdpi.com
Here, our data provide the first evidence for the existence of a previously unknown receptive
system formed by novel DNA-and RNA-based receptors in eukaryotes. This system, named …

Transcriptomic insights on the virulence-controlling CsrA, BadR, RpoN, and RpoS regulatory networks in the Lyme disease spirochete

WK Arnold, CR Savage, KG Lethbridge, TC Smith 2nd… - PLoS …, 2018 - journals.plos.org
Borrelia burgdorferi, the causative agent of Lyme disease, survives in nature through a cycle
that alternates between ticks and vertebrates. To facilitate this defined lifestyle, B. burgdorferi …