Regulation of filaggrin, loricrin, and involucrin by IL-4, IL-13, IL-17A, IL-22, AHR, and NRF2: pathogenic implications in atopic dermatitis

M Furue - International journal of molecular sciences, 2020 - mdpi.com
Atopic dermatitis (AD) is an eczematous, pruritic skin disorder with extensive barrier
dysfunction and elevated interleukin (IL)-4 and IL-13 signatures. The barrier dysfunction …

Aryl hydrocarbon receptor ligands in cancer: friend and foe

IA Murray, AD Patterson, GH Perdew - Nature Reviews Cancer, 2014 - nature.com
The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that is best
known for mediating the toxicity and tumour-promoting properties of the carcinogen 2, 3, 7, 8 …

The role of Th17-related cytokines in atopic dermatitis

M Sugaya - International journal of molecular sciences, 2020 - mdpi.com
T helper-17 (Th17) cells, which mainly produce IL-17, are associated with development of
various autoimmune diseases such as rheumatoid arthritis, inflammatory bowel diseases …

Aryl hydrocarbon receptor in atopic dermatitis and psoriasis

M Furue, A Hashimoto-Hachiya, G Tsuji - International journal of …, 2019 - mdpi.com
The aryl hydrocarbon receptor (AHR)/AHR-nuclear translocator (ARNT) system is a sensitive
sensor for small molecular, xenobiotic chemicals of exogenous and endogenous origin …

The science behind microgreens as an exciting new food for the 21st century

U Choe, LL Yu, TTY Wang - Journal of agricultural and food …, 2018 - ACS Publications
Chronic diseases are a major health problem in the United States. Accumulated data
suggest that consumption of vegetables can significantly reduce the risk of many chronic …

Functions of the aryl hydrocarbon receptor (AHR) beyond the canonical AHR/ARNT signaling pathway

NC Sondermann, S Faßbender, F Hartung… - Biochemical …, 2023 - Elsevier
The aryl hydrocarbon receptor (AHR) is a ligand-dependent transcription factor regulating
adaptive and maladaptive responses toward exogenous and endogenous signals …

The aryl hydrocarbon receptor in barrier organ physiology, immunology, and toxicology

C Esser, A Rannug - Pharmacological reviews, 2015 - ASPET
The aryl hydrocarbon receptor (AhR) is an evolutionarily old transcription factor belonging to
the Per-ARNT-Sim–basic helix-loop-helix protein family. AhR translocates into the nucleus …

Aryl hydrocarbon receptor signaling mediates expression of indoleamine 2, 3-dioxygenase

CFA Vogel, SR Goth, B Dong, IN Pessah… - Biochemical and …, 2008 - Elsevier
Aryl hydrocarbon receptor (AhR) activation by 2, 3, 7, 8-tetrachlorodibenzio-p-dioxin (TCDD)
leads to immune suppression associated with the induction of regulatory T cells (Treg) …

The roles of aryl hydrocarbon receptor in immune responses

NT Nguyen, H Hanieh, T Nakahama… - International …, 2013 - academic.oup.com
A number of recent studies have examined the functions of aryl hydrocarbon receptor (Ahr)
in the immune system. Also known as dioxin receptor, Ahr is a ligand-activated transcription …

Role of aryl hydrocarbon receptor in cancer

S Feng, Z Cao, X Wang - Biochimica et Biophysica Acta (BBA)-Reviews on …, 2013 - Elsevier
Aryl hydrocarbon receptor (AHR), a cytosolic ligand-activated transcription factor, belongs to
the member of bHLH/PAS family of heterodimeric transcriptional regulators and is widely …