TGF-β signaling in the tumor metabolic microenvironment and targeted therapies
X Shi, J Yang, S Deng, H Xu, D Wu, Q Zeng… - Journal of Hematology & …, 2022 - Springer
Transforming growth factor-β (TGF-β) signaling has a paradoxical role in cancer
progression, and it acts as a tumor suppressor in the early stages but a tumor promoter in …
progression, and it acts as a tumor suppressor in the early stages but a tumor promoter in …
[HTML][HTML] Targeting PP2A in cancer: Combination therapies
S Mazhar, SE Taylor, J Sangodkar, G Narla - Biochimica et Biophysica Acta …, 2019 - Elsevier
The serine/threonine phosphatase PP2A regulates a vast portion of the phosphoproteome
including pathways involved in apoptosis, proliferation and DNA damage response and …
including pathways involved in apoptosis, proliferation and DNA damage response and …
Obesity‐linked gut microbiome dysbiosis associated with derangements in gut permeability and intestinal cellular homeostasis independent of diet
This study aimed to determine the association between non‐high‐fat diet‐induced obesity‐
(non‐DIO‐) associated gut microbiome dysbiosis with gut abnormalities like cellular turnover …
(non‐DIO‐) associated gut microbiome dysbiosis with gut abnormalities like cellular turnover …
[HTML][HTML] Exploring the liver fibrosis induced by deltamethrin exposure in quails and elucidating the protective mechanism of resveratrol
S Li, X Zheng, X Zhang, H Yu, B Han, Y Lv, Y Liu… - Ecotoxicology and …, 2021 - Elsevier
Deltamethrin (DLM) is widely used in agriculture and the prevention of human insect-borne
diseases. However, the molecular mechanism of DLM induced liver injury remains unclear …
diseases. However, the molecular mechanism of DLM induced liver injury remains unclear …
Prebiotics from acorn and sago prevent high-fat-diet-induced insulin resistance via microbiome–gut–brain axis modulation
Role of gut microbiome in obesity and type 2 diabetes (T2D) became apparent from several
independent studies indicating that gut microbiome modulators like prebiotics may improve …
independent studies indicating that gut microbiome modulators like prebiotics may improve …
Cathepsin W restrains peripheral regulatory T cells for mucosal immune quiescence
Peripheral regulatory T (pTreg) cells are a key T cell lineage for mucosal immune tolerance
and anti-inflammatory responses, and interleukin-2 receptor (IL-2R) signaling is critical for …
and anti-inflammatory responses, and interleukin-2 receptor (IL-2R) signaling is critical for …
[HTML][HTML] Abnormalities in microbiota/butyrate/FFAR3 signaling in aging gut impair brain function
Aging-related abnormalities in gut microbiota are associated with cognitive decline,
depression, and anxiety, but underlying mechanisms remain unstudied. Here, our study …
depression, and anxiety, but underlying mechanisms remain unstudied. Here, our study …
FoxO transcription factors in cancer metabolism
RK Yadav, AS Chauhan, L Zhuang, B Gan - Seminars in cancer biology, 2018 - Elsevier
FoxO transcription factors serve as the central regulator of cellular homeostasis and are
tumor suppressors in human cancers. Recent studies have revealed that, besides their …
tumor suppressors in human cancers. Recent studies have revealed that, besides their …
Long Noncoding RNA ELIT-1 Acts as a Smad3 Cofactor to Facilitate TGFβ/Smad Signaling and Promote Epithelial–Mesenchymal Transition
S Sakai, T Ohhata, K Kitagawa, C Uchida, T Aoshima… - Cancer research, 2019 - AACR
TGFβ is involved in various biological processes, including development, differentiation,
growth regulation, and epithelial–mesenchymal transition (EMT). In TGFβ/Smad signaling …
growth regulation, and epithelial–mesenchymal transition (EMT). In TGFβ/Smad signaling …
FOXO family in regulating cancer and metabolism
J Ma, S Matkar, X He, X Hua - Seminars in cancer biology, 2018 - Elsevier
FOXO proteins are a sub-group of a superfamily of forkhead box (FOX)-containing
transcription factors (TFs). FOXOs play an important role in regulating a plethora of …
transcription factors (TFs). FOXOs play an important role in regulating a plethora of …