For a long time, PLS3 (plastin 3, also known as T-plastin or fimbrin) has been considered a
rather inconspicuous protein, involved in F-actin-binding and-bundling. However, in recent …

DNA damage, provoked by ultraviolet (UV) radiation, evokes a cellular damage response
composed of activation of stress signaling and DNA checkpoint functions. These are …

Circulating tumor cells (CTC) in blood have attracted attention both as potential seeds for
metastasis and as biomarkers. However, most CTC detection systems might miss epithelial …

In higher animal cells, duplication of centrosomes is triggered by CDK2/cyclin E-mediated
phosphorylation. Nucleophosmin (NPM)/B23, a multifunctional protein, has recently been …

Many actin‐binding proteins are expressed in eukaryotic cells. These polypep‐tides assist in
stabilizing and rearranging the organization of the actin cytoskeleton in response to external …

We have previously shown that specific RNA-binding proteins (RBP) are activated by
genotoxic stress. The role and function of these stress-activated RBP are, however, poorly …

Genotoxic stress (DNA damage) can elicit multiple responses in mammalian cells, including
the activation of numerous cascades of signal transduction that result in the activation of …

Nucleophosmin/B23 was rapidly up-regulated after UV irradiation as p53, PCNA and c-Jun.
UV induction of nucleophosmin/B23 was evidently increased at 3 h post-irradiation, and …

The pathogenesis of acute myeloid leukemia is associated with the appearance of
oncogenic fusion proteins generated as a consequence of specific chromosome …

Vinca alkaloids are used widely in the treatment of both childhood and adult cancers. Their
cellular target is the β-tubulin subunit of α/β-tubulin heterodimers, and they act to inhibit cell …