Alternative polyadenylation of mRNA precursors
Alternative polyadenylation (APA) is an RNA-processing mechanism that generates distinct
3′ termini on mRNAs and other RNA polymerase II transcripts. It is widespread across all …
3′ termini on mRNAs and other RNA polymerase II transcripts. It is widespread across all …
RNA G-quadruplexes in biology: principles and molecular mechanisms
Abstract G-quadruplexes (G4s) are extremely stable DNA or RNA secondary structures
formed by sequences rich in guanine. These structures are implicated in many essential …
formed by sequences rich in guanine. These structures are implicated in many essential …
Alternative cleavage and polyadenylation: extent, regulation and function
The 3′ end of most protein-coding genes and long non-coding RNAs is cleaved and
polyadenylated. Recent discoveries have revealed that a large proportion of these genes …
polyadenylated. Recent discoveries have revealed that a large proportion of these genes …
Mechanisms and consequences of alternative polyadenylation
DC Di Giammartino, K Nishida, JL Manley - Molecular cell, 2011 - cell.com
Alternative polyadenylation (APA) is emerging as a widespread mechanism used to control
gene expression. Like alternative splicing, usage of alternative poly (A) sites allows a single …
gene expression. Like alternative splicing, usage of alternative poly (A) sites allows a single …
[HTML][HTML] Ending the message: poly (A) signals then and now
NJ Proudfoot - Genes & development, 2011 - genesdev.cshlp.org
Abstract Polyadenylation [poly (A)] signals (PAS) are a defining feature of eukaryotic protein-
coding genes. The central sequence motif AAUAAA was identified in the mid-1970s and …
coding genes. The central sequence motif AAUAAA was identified in the mid-1970s and …
U1 snRNP protects pre-mRNAs from premature cleavage and polyadenylation
In eukaryotes, U1 small nuclear ribonucleoprotein (snRNP) forms spliceosomes in equal
stoichiometry with U2, U4, U5 and U6 snRNPs; however, its abundance in human far …
stoichiometry with U2, U4, U5 and U6 snRNPs; however, its abundance in human far …
RNA processing and its regulation: global insights into biological networks
DD Licatalosi, RB Darnell - Nature Reviews Genetics, 2010 - nature.com
In recent years views of eukaryotic gene expression have been transformed by the finding
that enormous diversity can be generated at the RNA level. Advances in technologies for …
that enormous diversity can be generated at the RNA level. Advances in technologies for …
The role of the 3'untranslated region in post-transcriptional regulation of protein expression in mammalian cells.
E Matoulkova, E Michalova, B Vojtesek, R Hrstka - RNA biology, 2012 - Taylor & Francis
The untranslated regions (UTRs) at the 3'end of mRNA transcripts contain important
sequences that influence the fate of mRNA and thus proteosynthesis. In this review, we …
sequences that influence the fate of mRNA and thus proteosynthesis. In this review, we …
Metabolism and regulation of canonical histone mRNAs: life without a poly (A) tail
WF Marzluff, EJ Wagner, RJ Duronio - Nature Reviews Genetics, 2008 - nature.com
The canonical histone proteins are encoded by replication-dependent genes and must
rapidly reach high levels of expression during S phase. In metazoans the genes that encode …
rapidly reach high levels of expression during S phase. In metazoans the genes that encode …
Formation, regulation and evolution of Caenorhabditis elegans 3′UTRs
Post-transcriptional gene regulation frequently occurs through elements in mRNA 3′
untranslated regions (UTRs),. Although crucial roles for 3′ UTR-mediated gene regulation …
untranslated regions (UTRs),. Although crucial roles for 3′ UTR-mediated gene regulation …