Microsatellite instability (MSI) is a hypermutable phenotype caused by the loss of DNA
mismatch repair activity. MSI is detected in about 15% of all colorectal cancers; 3% are of …

Microsatellite instability (MSI) is a molecular marker of a deficient mismatch repair (MMR)
system and occurs in approximately 15% of colorectal cancers (CRCs), more frequently in …

Purpose: To determine the prevalence and prognostic value of mismatch repair (MMR)
status and its relation to BRAF mutation (BRAF MT) status in metastatic colorectal cancer …

Background Colorectal cancer (CRC) is a leading cause of cancer-associated deaths with
liver metastases developing in 25–30% of those affected. Previous data suggest a survival …

Purpose Cetuximab or panitumumab are effective in 10% to 20% unselected metastatic
colorectal cancer (CRC) patients. KRAS mutations account for approximately 30% to 40 …

Purpose Recent studies have reported increased mortality for right-sided colon cancers but
had limited adjustment for patient characteristics and conflicting results by stage. We …

Purpose: Tumor-infiltrating T lymphocytes (TIL) play a key role in the clinical outcome of
human colorectal cancer; however, the dynamics of their recruitment along colorectal cancer …

A deficient mismatch repair system (dMMR) is present in 10–20% of patients with sporadic
colorectal cancer (CRC) and is associated with a favourable prognosis in early stage …

2.1 Geltungsbereich und Zweck 2.1. 1. Zielsetzung und Fragestellung Das Kolorektale
Karzinom (KRK) ist mit etwa 64 000 Neuerkrankungen und ca. 26 000 Todesfällen pro Jahr …

Background The incidence of right-sided colon cancers has been increasing in recent years.
It is unclear whether patient prognosis varies by tumor location. In this study, we have …