Embryonic stem cell (ESC) markers are molecules specifically expressed in ES cells.
Understanding of the functions of these markers is critical for characterization and …

High mobility group (HMG) proteins are the most abundant non-histone chromatin
associated proteins. HMG proteins bind to DNA and nucleosome and alter the structure of …

Nucleic acids are powerful triggers of innate immunity and can adopt the Z-conformation, an
unusual left-handed double helix. Here, we studied the biological function (s) of Z-RNA …

Despite the high prevalence and poor outcome of patients with metastatic lung cancer the
mechanisms of tumour progression and metastasis remain largely uncharacterized. Here we …

Abstract PI3K (phosphoinositide 3-kinase)/AKT and RAS/MAPK (mitogen-activated protein
kinase) pathway coactivation in the prostate epithelium promotes both epithelial …

Rationale: Endothelial progenitor cells (EPCs) contribute to the regeneration of endothelium.
Aging-associated senescence results in reduced number and function of EPCs, potentially …

Background Generating autologous pluripotent stem cells for therapeutic applications will
require the development of efficient DNA-free reprogramming techniques. Transfecting cells …

Proinflammatory macrophage (M1) is now being suggested as a potential therapeutic
strategy for cancer because of its tumoricidal capacity. However, few studies have been …

HMGA1 and HMGA2 are chromatin architectural proteins that do not have transcriptional
activity per se, but are able to modify chromatin structure by interacting with the …

Small non-coding RNAs–microRNAs, are potent negative regulators of gene expression.
MicroRNAs are involved in multiple biological processes, metabolic regulation, including …