[HTML][HTML] Viral proteases as therapeutic targets

T Majerová, J Konvalinka - Molecular aspects of medicine, 2022 - Elsevier
Some medically important viruses―including retroviruses, flaviviruses, coronaviruses, and
herpesviruses―code for a protease, which is indispensable for viral maturation and …

Ferrocene derivatives as anti-infective agents

BS Ludwig, JDG Correia, FE Kühn - Coordination Chemistry Reviews, 2019 - Elsevier
Infectious diseases like malaria, tuberculosis or HIV are among the leading causes of death
worldwide according to WHO estimations. Nevertheless, the fight against infectious diseases …

Nucleotide analogues as inhibitors of SARS-CoV-2 polymerase, a key drug target for COVID-19

M Chien, TK Anderson, S Jockusch, C Tao… - Journal of proteome …, 2020 - ACS Publications
SARS-CoV-2 is responsible for the current COVID-19 pandemic. On the basis of our
analysis of hepatitis C virus and coronavirus replication, and the molecular structures and …

A library of nucleotide analogues terminate RNA synthesis catalyzed by polymerases of coronaviruses that cause SARS and COVID-19

S Jockusch, C Tao, X Li, TK Anderson, M Chien… - Antiviral research, 2020 - Elsevier
Abstract SARS-CoV-2, a member of the coronavirus family, is responsible for the current
COVID-19 worldwide pandemic. We previously demonstrated that five nucleotide analogues …

Sofosbuvir terminated RNA is more resistant to SARS-CoV-2 proofreader than RNA terminated by Remdesivir

S Jockusch, C Tao, X Li, M Chien, S Kumar… - Scientific reports, 2020 - nature.com
SARS-CoV-2 is responsible for COVID-19, resulting in the largest pandemic in over a
hundred years. After examining the molecular structures and activities of hepatitis C viral …

Nucleotide analogues as inhibitors of SARS‐CoV polymerase

J Ju, X Li, S Kumar, S Jockusch… - Pharmacology …, 2020 - Wiley Online Library
Abstract SARS‐CoV‐2, a member of the coronavirus family, has caused a global public
health emergency. Based on our analysis of hepatitis C virus and coronavirus replication …

Drug design strategies for the treatment of viral disease. Plant phenolic compounds and their derivatives

M Kowalczyk, A Golonko, R Świsłocka… - Frontiers in …, 2021 - frontiersin.org
The coronavirus pandemic (SARS CoV-2) that has existed for over a year, constantly forces
scientists to search for drugs against this virus. In silico research and selected experimental …

[HTML][HTML] Efficacy and safety of sofosbuvir/ledipasvir in treatment of patients with COVID-19; A randomized clinical trial

A Nourian, H Khalili, Z Ahmadinejad… - Acta Bio Medica …, 2020 - ncbi.nlm.nih.gov
Background: There is no study regarding the use of SOF/LDP in treatment of COVID-19.
Objectives: In this study, the efficacy and safety of SOF/LDP were assessed in treatment of …

[HTML][HTML] Changes of gut-microbiota-liver axis in hepatitis C virus infection

M El-Mowafy, A Elgaml, M El-Mesery, S Sultan… - Biology, 2021 - mdpi.com
The gut–liver-axis is a bidirectional coordination between the gut, including microbial
residents, the gut microbiota, from one side and the liver on the other side. Any disturbance …

New opportunities to individualize frontline therapy in advanced stages of hepatocellular carcinoma

JD Gordan, BP Keenan, HC Lim, M Yarchoan… - Drugs, 2023 - Springer
Hepatocellular carcinoma (HCC) is a leading cause of cancer death globally and is rising in
incidence. Until recently, treatment options for patients with advanced stages of HCC have …