Fluorine, often called as “a small atom with a big ego”, 1 lies in the second row and the 17th
column in the periodic table of the chemical elements. This unique position in the periodic …

The gem-difluoroalkenes and related compounds have gained much attention from the
organic synthetic community due to their widespread applications as versatile fluorinated …

Herein we report a chromium-catalyzed allylic defluorinative ketyl olefin coupling between
aldehydes and α-trifluoromethyl alkenes, which provides novel and efficient access to …

Allylation reactions are one of the most fundamental and productive C− C bond-forming
transformations, as the allyl group can provide a useful handle for further manipulation …

A new olefination protocol for transition-metal-free cross-coupling of two carbene fragments
arising from two different sources, namely, a nonfluorinated carbene fragment resulting from …

The combination of photoredox catalysis with the Wolff–Kishner (WK) reaction allows the
difunctionalization of carbonyl groups by a radical-carbanion relay sequence (photo-Wolff …

In this protocol, we report an allylic defluorinative reductive cross-coupling reaction for C–C
bond formation. Under the Ni-catalysis the challenging C (sp3)–F bond cleavage of …

We report the first iron-catalyzed difluoromethylation of arylzincs with difluoromethyl 2-
pyridyl sulfone via selective C–S bond cleavage. This method employs the readily available …

Summary gem-Difluoroalkenes have steric and electronic profiles similar to those of
ketones, aldehydes, and esters, and consequently have been used widely as carbonyl …

A transition‐metal‐free difluoromethylenation of diazo compounds that proceeds under mild
conditions has been developed and is based on the use of TMSCF2Br as the …