The genetic basis of major depression
Major depressive disorder (MDD) is a common, debilitating, phenotypically heterogeneous
disorder with heritability ranges from 30% to 50%. Compared to other psychiatric disorders …
disorder with heritability ranges from 30% to 50%. Compared to other psychiatric disorders …
Reviewing the genetics of heterogeneity in depression: operationalizations, manifestations and etiologies
With progress in genome-wide association studies of depression, from identifying zero hits
in~ 16 000 individuals in 2013 to 223 hits in more than a million individuals in 2020 …
in~ 16 000 individuals in 2013 to 223 hits in more than a million individuals in 2020 …
Structural and functional deficits and couplings in the cortico-striato-thalamo-cerebellar circuitry in social anxiety disorder
X Zhang, X Suo, X Yang, H Lai, N Pan, M He… - Translational …, 2022 - nature.com
Although functional and structural abnormalities in brain regions involved in the
neurobiology of fear and anxiety have been observed in patients with social anxiety disorder …
neurobiology of fear and anxiety have been observed in patients with social anxiety disorder …
The genetic determinants of language network dysconnectivity in drug-naïve early stage schizophrenia
Schizophrenia is a neurocognitive illness of synaptic and brain network-level
dysconnectivity that often reaches a persistent chronic stage in many patients. Subtle …
dysconnectivity that often reaches a persistent chronic stage in many patients. Subtle …
[HTML][HTML] Immune dysregulation in depression: Evidence from genome-wide association
A strong body of evidence supports a role for immune dysregulation across many psychiatric
disorders including depression, the leading cause of global disability. Recent progress in …
disorders including depression, the leading cause of global disability. Recent progress in …
Genetics and major depressive disorder: clinical implications for disease risk, prognosis and treatment
In the post-genomic era, genetics has led to limited clinical applications in the diagnosis and
treatment of major depressive disorder (MDD). Variants in genes coding for cytochrome …
treatment of major depressive disorder (MDD). Variants in genes coding for cytochrome …
Mutational landscape of risk variants in comorbid depression and obesity: a next-generation sequencing approach
Major depression (MD) and obesity are complex genetic disorders that are frequently
comorbid. However, the study of both diseases concurrently remains poorly addressed and …
comorbid. However, the study of both diseases concurrently remains poorly addressed and …
Identifying changes of brain regional homogeneity and cingulo-opercular network connectivity in first-episode, drug-naïve depressive patients with suicidal ideation
M He, L Ping, Z Chu, C Zeng, Z Shen… - Frontiers in neuroscience, 2022 - frontiersin.org
Objective Adult patients with major depressive disorder (MDD) may not actively reveal their
suicidal ideation (SI). Therefore, this study is committed to finding the alterations in the …
suicidal ideation (SI). Therefore, this study is committed to finding the alterations in the …
Genetic variations in the retrograde endocannabinoid signaling pathway in Chinese patients with major depressive disorder
Background The retrograde endocannabinoid (eCB) pathway is closely associated with the
etiology of major depressive disorder (MDD) at both pathophysiological and genetic levels …
etiology of major depressive disorder (MDD) at both pathophysiological and genetic levels …
Association analysis between catechol-O-methyltransferase expression and cognitive function in patients with schizophrenia, bipolar disorder, or major depression
P Ni, M Liu, D Wang, Y Tian, L Zhao, J Wei… - Neuropsychiatric …, 2021 - Taylor & Francis
Introduction Schizophrenia, bipolar disorder (BD), and major depressive disorder are three
common mental disorders. Although their diagnosis and treatment differ, they partially …
common mental disorders. Although their diagnosis and treatment differ, they partially …