It has been one and a half centuries since Enrico Sertoli published the seminal discovery of
the testicular 'nurse cell', not only a key cell in the testis, but indeed one of the most amazing …

Spermatogenesis is a complex biological process of cellular transformation that produces
male haploid germ cells from diploid spermatogonial stem cells. This process has been …

Spermatogenesis requires intricate interactions between the germline and somatic cells.
Within a given cross section of a seminiferous tubule, multiple germ and somatic cell types …

Reproduction is required for the survival of all mammalian species, and thousands of
essential'sex'genes are conserved through evolution. Basic research helps to define these …

Spermatogonial stem cells (SSCs) are the most primitive spermatogonia in the testis and
have an essential role to maintain highly productive spermatogenesis by self-renewal and …

Spermatogenesis is a continuous and productive process supported by the self-renewal and
differentiation of spermatogonial stem cells (SSCs), which arise from undifferentiated …

Male infertility is a multifactorial complex disease with highly heterogeneous phenotypic
representation and in at least 15% of cases, this condition is related to known genetic …

Mammalian male germ cell development is a stepwise cell-fate transition process; however,
the full-term developmental profile of male germ cells remains undefined. Here, by …

The two major components of the kidney, the collecting system and the nephron, have
different developmental histories. The collecting system arises by the reiterated branching of …

Stem cells are rare cells that are uniquely capable of both reproducing themselves (self-
renewing) and generating the differentiated cell types that are needed to carry out …