The role of natural killer cells in autoimmune diseases

UC Kucuksezer, E Aktas Cetin, F Esen… - Frontiers in …, 2021 - frontiersin.org
Natural killer (NK) cells, the large granular lymphocytes differentiated from the common
lymphoid progenitors, were discovered in early 1970's. They are members of innate …

[HTML][HTML] Natural killer cells in SARS-CoV-2 infection: pathophysiology and therapeutic implications

C Di Vito, F Calcaterra, N Coianiz, S Terzoli… - Frontiers in …, 2022 - frontiersin.org
Natural Killer (NK) cells are lymphocytes of the innate immunity that play a crucial role in the
control of viral infections in the absence of a prior antigen sensitization. Indeed, they display …

[HTML][HTML] Dysconnectivity of a brain functional network was associated with blood inflammatory markers in depression

AR Aruldass, MG Kitzbichler, SE Morgan, S Lim… - Brain, behavior, and …, 2021 - Elsevier
Objective There is increasing evidence for a subgroup of major depressive disorder (MDD)
associated with heightened peripheral blood inflammatory markers. In this study, we aimed …

Pathological and protective roles of dendritic cells in Mycobacterium tuberculosis infection: Interaction between host immune responses and pathogen evasion

H Kim, SJ Shin - Frontiers in Cellular and Infection Microbiology, 2022 - frontiersin.org
Dendritic cells (DCs) are principal defense components that play multifactorial roles in
translating innate immune responses to adaptive immunity in Mycobacterium tuberculosis …

Polysaccharides from Spores of Cordyceps cicadae Protect against Cyclophosphamide-Induced Immunosuppression and Oxidative Stress in Mice

Y Zheng, S Li, C Li, Y Shao, A Chen - Foods, 2022 - mdpi.com
This study investigated the purification, preliminary structure and in vivo immunomodulatory
activities of polysaccharides from the spores of Cordyceps cicadae (CCSP). The crude …

Neutropenia and Large granular lymphocyte leukemia: From pathogenesis to therapeutic options

G Calabretto, A Teramo, G Barilà, C Vicenzetto… - Cells, 2021 - mdpi.com
Large granular lymphocyte leukemia (LGLL) is a rare lymphoproliferative disorder
characterized by the clonal expansion of cytotoxic T-LGL or NK cells. Chronic isolated …

Distinct Human NK Cell Phenotypes and Functional Responses to Mycobacterium tuberculosis in Adults From TB Endemic and Non-endemic Regions

LD Harris, J Khayumbi, J Ongalo, LE Sasser… - Frontiers in cellular …, 2020 - frontiersin.org
Mycobacterium tuberculosis (Mtb) is the causative agent of tuberculosis (TB), which leads to
an estimated 1. 5 million deaths worldwide each year. Although the immune correlates of …

Understanding the synergy of NKp46 and co-activating signals in various NK cell subpopulations: paving the way for more successful NK-cell-based immunotherapy

L Zamai, G Del Zotto, F Buccella, S Gabrielli… - Cells, 2020 - mdpi.com
The NK cell population is characterized by distinct NK cell subsets that respond differently to
the various activating stimuli. For this reason, the determination of the optimal cytotoxic …

Vaccine therapy in hematologic malignancies

D Avigan, J Rosenblatt - Blood, The Journal of the American …, 2018 - ashpublications.org
Immune-based therapy has emerged as a paradigm shift in cancer therapy with dramatic
responses observed in previously incurable disease. Cancer vaccines are being developed …

When and how NK cell-induced programmed cell death benefits immunological protection against intracellular pathogen infection

JE Belizário, JM Neyra… - Innate …, 2018 - journals.sagepub.com
NK cells are innate lymphoid cells that exert a key role in immune surveillance through the
recognition and elimination of transformed cells and viral, bacterial, and protozoan pathogen …