Conspectus Functional ligands consist of a wide range of small or large molecules that
exhibit a spectrum of physical, chemical, and biological properties. A suite of small …

Nanomedicine has emerged as a promising therapeutic approach, but its translation to the
clinic has been hindered by the lack of cellular models to anticipate how tumor cells will …

The in vivo fate of chemotherapeutic drugs plays a vital role in understanding the therapeutic
outcome, side effects, and the mechanism. However, the lack of imaging abilities of drugs …

Small molecules, including therapeutic drugs and tracer molecules, play a vital role in
biological processing, disease treatment and diagnosis, and have inspired various …

Poly (ethylene glycol)(PEG) is considered to be the “gold standard” among the stealth
polymers employed for drug delivery. Using PEG to modify or engineer particles has thus …

Microfluidics opens new avenues for materials engineering, as it enables scalable synthesis
and provides highly controllable environments for reactions. Herein, we leverage …

Chemotherapy is the main treatment method for osteosarcoma in the clinic. However, drug
resistance and its poor antimetastatic effects greatly limit its clinical application. In this work …

A new type of polymeric nanomicelle-based nanoagent (denoted as PT@ MFH hereafter)
capable of the highly sensitive release of the chemotherapeutic drug paclitaxel (PTX) upon …

Cancer is one of the biggest threats to human health with a global incidence of 23.6 million,
mortality of 10 million, and an estimated 250 million lost in disability-adjusted life years …

Immune checkpoint blockade therapy has made great strides in cancer treatment, but
conventional immune checkpoint blockade antibodies often lead to overactivation of the …