Bones are able to withstand functional loads without either breaking or sustaining extensive
damage because they have evolved the capacity to adapt their architecture in relation to …

Prior to initiating a clinical trial in a post-menopausal osteoporosis study, it is reasonable to
recommence the evaluation of treatment in the 9-month-old ovariectomized female rat. A …

Bone modeling is a mechanically mediated adaptive process for changing a bone's size,
shape, or position. Site specific, anabolic and catabolic modeling events are manifestations …

Bone formation can be remodeling‐based (RBF) or modeling‐based (MBF), the former
coupled to bone resorption and the latter occurring directly on quiescent surfaces. Unlike …

Transiliac bone biopsies were obtained from 55 women treated with teriparatide or placebo
for 12–24 months. We report direct evidence that modeling bone formation at quiescent …

This minireview on skeletal biology describes the actions of prostaglandins and cytokines
involved in the local regulation of bone metabolism, it documents the role of lipids in bone …

The disability, mortality and costs caused by non-vertebral osteoporotic fractures are
enormous. Existing osteoporosis therapies are highly effective at reducing vertebral but not …

Accumulating evidence indicates that TNFα plays an important role in the pathogenesis of
periodontitis, but the effect of TNFα on the degradation of the periodontal ligament is not well …

Prostaglandins mediate adaptive bone formation induced by mechanical loading. Inhibition
of cyclooxygenase-2 (COX-2) with NS-398 effectively blocks loading-induced osteogenesis …

ATTEMPTS TO REPAIR skeletal and dental defects with synthetic and natural materials,
including bone autografts, have been made for centuries. 1, 2 Bone graft therapy is currently …