As we age, we experience changes in our nighttime sleep and daytime wakefulness.
Individuals afflicted with Alzheimer's disease (AD) can develop sleep problems even before …

Hereditary frontotemporal dementia associated with mutations in the microtubule‐
associated protein tau gene (MAPT) is a protean disorder. Three neuropathologic subtypes …

Curcumin (diferuloylmethane), a polyphenol extracted from the plant Curcuma longa, is
widely used in Southeast Asia, China and India in food preparation and for medicinal …

The accumulation of protein inclusions is linked to many neurodegenerative diseases that
typically develop in older individuals, due to a combination of genetic and environmental …

Tauopathies are classified according to whether tau deposits predominantly contain tau
isoforms with three or four repeats of the microtubule-binding domain. Those in which four …

It has been more than 10 years since it was first proposed that the neurodegeneration in
Alzheimer's disease (AD) may be caused by deposition of amyloid β-peptide (Aβ) in plaques …

It has been understood for decades that certain sporting activities may increase an athlete's
risk of developing a neurodegenerative disease later in life. Not surprisingly, this association …

Thirteen families have been described with an autosomal dominantly inherited dementia
named frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP …

▪ Abstract The defining neuropathological characteristics of Alzheimer's disease are
abundant filamentous tau lesions and deposits of fibrillar amyloid β peptides. Prominent …

Tau proteins belong to the family of microtubule-associated proteins. They are mainly
expressed in neurons where they play an important role in the assembly of tubulin …