Identification and treatment of latent tuberculosis infection (LTBI) can substantially reduce
the risk of developing active disease. However, there is no diagnostic gold standard for LTBI …

Background We aimed to assess whether interferon-γ release assays (IGRAs) can predict
the development of active tuberculosis and whether the predictive ability of these tests is …

Currently there are no sufficiently validated biomarkers to aid the evaluation of new
tuberculosis vaccine candidates, the improvement of tuberculosis diagnostics or the …

Tuberculosis (TB) remains a threat to the health of people worldwide. Infection with
Mycobacterium tuberculosis can result in active TB or, more commonly, latent infection …

Tuberculosis control relies on the identification and preventive treatment of individuals who
are latently infected with Mycobacterium tuberculosis. However, direct identification of latent …

Human infection with Mycobacterium tuberculosis can progress to active disease, be
contained as latent infection, or be eradicated by the host response. Tuberculosis …

A major challenge in tuberculosis control is the diagnosis and treatment of latent
tuberculosis infection. Until recently, there were no alternatives to the tuberculin skin test …

Background Given the current lack of effective vaccines against TB, the accuracy of
screening tests for determining or excluding latent TB infection (LTBI) is decisive in effective …

We previously described that low-dose Mycobacterium tuberculosis infection in cynomolgus
macaques results in a spectrum of disease similar to that of human infection: primary …

The tuberculin skin test for immunologic diagnosis of Mycobacterium tuberculosis infection
has many limitations, including being confounded by bacillus Calmette-Guérin (BCG) …