Cancer is the second leading cause of human death globally. PI3K/Akt/mTOR signaling is
one of the most frequently dysregulated signaling pathways observed in cancer patients that …

Kinases have emerged as one of the most intensively pursued targets in current
pharmacological research, especially for cancer, due to their critical roles in cellular …

Highlights•A dramatic increase in the approval of small molecule kinase inhibitors
(SMKIs).•The molecular weight of most approved SMKIs is in the range of 400–600.•The …

Pathological Unfoldomics of Uncontrolled Chaos: Intrinsically Disordered Proteins and Human
Diseases | Chemical Reviews ACS ACS Publications C&EN CAS Find my institution Log In …

The Akt family of serine/threonine protein kinases are key regulators of multiple aspects of
cell behaviour, including proliferation, survival, metabolism, and tumorigenesis. Growth …

Small-molecule kinase inhibitors are invaluable targeted therapeutics for the treatment of
various human diseases, especially cancers. While the majority of approved and developed …

Autophagy is a basic catabolic process, serving as an internal engine during responses to
various cellular stresses. As regards cancer, autophagy may play a tumor suppressive role …

Background Recent epidemiologic studies suggesting that there were differences in cancer
recurrence contingent on anesthetic regimens have raised the possibility that μ-opioid …

The role of salidroside in colon cancer remains unknown. Here we show that salidroside, a
phenylpropanoid glycoside extracted from Rhodiola rosea, exhibited potent anti-proliferative …

Fish have provided essential information about the structure, biosynthesis, evolution, and
function of insulin (INS) as well as about the structure, evolution, and mechanism of action of …