Molecular aspects of insulin aggregation and various therapeutic interventions
Protein aggregation leading to the formation of amyloid fibrils has various adverse effects on
human health ranging from fatigue and numbness to organ failure and death in extreme …
human health ranging from fatigue and numbness to organ failure and death in extreme …
Protein aggregation: from background to inhibition strategies
The aggregation of specific proteins is hypothesized to cause several pathological
conditions, which are collectively known as amyloid disorders. The aggregation of peptides …
conditions, which are collectively known as amyloid disorders. The aggregation of peptides …
Protein misfolding, aggregation and mechanism of amyloid cytotoxicity: An overview and therapeutic strategies to inhibit aggregation
Protein and peptides are converted from their soluble forms into highly ordered fibrillar
aggregates under various conditions inside the cell. Such transitions confer diverse …
aggregates under various conditions inside the cell. Such transitions confer diverse …
Insulin fibrillation: toward strategies for attenuating the process
M Akbarian, R Yousefi, F Farjadian… - Chemical …, 2020 - pubs.rsc.org
Dark days for diabetic patients were transformed into an era of hope when the therapeutic
usage of insulin was discovered. However, those initial glory days changed to being …
usage of insulin was discovered. However, those initial glory days changed to being …
Amyloid protein-induced supramolecular self-assembly of water-soluble platinum (II) complexes: a luminescence assay for amyloid fibrillation detection and inhibitor …
Amyloid fibrillation has been acknowledged as a hallmark of a number of
neurodegenerative ailments such as Alzheimer's disease. Accordingly, efficient detection of …
neurodegenerative ailments such as Alzheimer's disease. Accordingly, efficient detection of …
Analysis of the binding selectivity and inhibiting mechanism of chlorogenic acid isomers and their interaction with grass carp endogenous lipase using multi …
Z Xu, Q Cao, A Manyande, S Xiong, H Du - Food Chemistry, 2022 - Elsevier
Polyphenols are inhibitors for lipase, but the binding selectivity and mechanism of
polyphenol isomers and how they interact with lipase are not clear. Here, chlorogenic acid …
polyphenol isomers and how they interact with lipase are not clear. Here, chlorogenic acid …
A quantitative meta-analysis of vitamin C in the pathophysiology of Alzheimer's disease
Purpose Alzheimer's disease (AD) is a multifaceted neurodegenerative disorder with many
complex pathways feeding into its pathogenesis and progression. Vitamin C, an essential …
complex pathways feeding into its pathogenesis and progression. Vitamin C, an essential …
Role of aromatic amino acids in amyloid self-assembly
Amyloids are proteins of a cross-β structure found as deposits in several diseases and also
in normal tissues (nails, spider net, silk). Aromatic amino acids are frequently found in …
in normal tissues (nails, spider net, silk). Aromatic amino acids are frequently found in …
Non-polyphenolic natural inhibitors of amyloid aggregation
L Ma, C Yang, J Zheng, Y Chen, Y Xiao… - European journal of …, 2020 - Elsevier
Protein misfolding diseases (PMDs) are chronic and progressive, with no effective therapy
so far. Aggregation and misfolding of amyloidogenic proteins are closely associated with the …
so far. Aggregation and misfolding of amyloidogenic proteins are closely associated with the …
Amyloid fibrillation of insulin: amelioration strategies and implications for translation
MHA Fagihi, S Bhattacharjee - ACS Pharmacology & …, 2022 - ACS Publications
Insulin is a therapeutically relevant molecule with use in treating diabetes patients.
Unfortunately, it undergoes a range of untoward and often unpredictable physical …
Unfortunately, it undergoes a range of untoward and often unpredictable physical …