The superficial zone of articular cartilage contributes to smooth joint motion through the
production of proteoglycan 4 (PRG4), also known as lubricin. Recent studies indicate novel …

Rho guanosine triphosphatase (GTPases), as molecular switches, have been identified to
be dysregulated and involved in the pathogenesis of various rheumatic diseases, mainly …

Background: Bioengineered cartilage is a developing therapeutic to repair cartilage defects.
The matrix must be rich in collagen type II and aggrecan and mechanically competent …

The roles of cell division control protein 42 homologue (CDC42) and actin polymerisation in
regulating the phenotype of superficial-zone chondrocytes (SZCs) have been demonstrated …

Background: Chondrocyte migration in native cartilage is limited and has been implicated as
one of the reasons for the poor integration of native implants. Through use of an in vitro …

Numerous small-molecule inhibitors (SMIs) have been approved as adjuvant or first-line
therapies for malignancies. Based on cancer treatment using SMIs, next-generation SMIs …

Objective The superficial zone (SZ) of articular cartilage is responsible for distributing shear
forces for optimal cartilage loading and contributes to joint lubrication through the production …

Actin is a central mediator of the chondrocyte phenotype. Monolayer expansion of articular
chondrocytes on tissue culture polystyrene, for cell-based repair therapies, leads to …

Objective The actin cytoskeleton regulates cell shape and plays a role in regulating
chondrocyte phenotype. Most studies investigating regulation of the chondrocyte phenotype …

Articular cartilage is incapable of self-repair and any damage to the tissue results in
degradation leading to Osteoarthritis. To prevent Osteoarthritis progression, cell-based …