Publisher Summary The chapter introduces the mitogen-activated protein (MAP) kinase
(MAPK) module. The identification of MAP kinase pathways exemplifies the power of …

Proteinase-activated receptors are a recently described, novel family of seven-
transmembrane G-protein-coupled receptors. Rather then being stimulated through ligand …

The Ras-dependent activation of mitogen-activated protein (MAP) kinase pathways by many
receptors coupled to heterotrimeric guanine nucleotide binding proteins (G proteins) …

THE paired helical filament (PHF) is the major component of the neurofibrillary deposits that
form a defining neuropathological characteristic of Alzheimer's disease (reviewed in refs 1 …

Cross-communication between different signalling systems allows the integration of the
great diversity of stimuli that a cell receives under varying physiological situations. The …

MAP kinases help to mediate diverse processes ranging from transcription of
protooncogenes to programmed cell death. More than a dozen mammalian MAP kinase …

Although serine proteases are usually considered to act principally as degradative enzymes,
certain proteases are signaling molecules that specifically regulate cells by cleaving and …

THE mechanisms by which mitogenic G-protein-coupled receptors activate the MAP kinase
signalling pathway are poorly understood. Candidate protein tyrosine kinases that link G …

The adapter protein Shc was initially identified as an SH2 containing proto-oncogene
involved in growth factor signaling. Since then a number of studies in multiple systems have …

Serine proteinases such as thrombin, mast cell tryptase, trypsin, or cathepsin G, for example,
are highly active mediators with diverse biological activities. So far, proteinases have been …