Shigella are gram-negative bacteria that cause severe diarrhea and dysentery. In 2013,
Shigella infections caused an estimated 34,400 deaths in children less than five years old …

More than 50 years of research has yielded numerous Shigella vaccine candidates that
have exemplified both the promise of vaccine-induced prevention of shigellosis and the …

Shigella Isolates From the Global Enteric Multicenter Study Inform Vaccine Development |
Clinical Infectious Diseases | Oxford Academic Skip to Main Content Advertisement Oxford …

Understanding the mechanisms underlying the induction of immunity in the gastrointestinal
mucosa following oral immunization and the cross‐talk between mucosal and systemic …

Norwalk virus-like particles (VLPs), made from recombinant capsid protein, are a promising
vaccine. Thirty-six healthy adult volunteers received 250 μg (n= 10), 500 μg (n= 10), or 2000 …

Shigella spp. are food-and waterborne pathogens that cause severe diarrheal and
dysenteric disease associated with high morbidity and mortality. Individuals most often …

The Shigella invasin complex or Invaplex vaccine is a unique subunit approach to generate
a protective immune response. Invaplex is a large, macromolecular complex consisting of …

Shigellosis is an acute, infectious, inflammatory enteritis of humans and, on occasion,
subhuman primates. Because it is often clinically manifested by the dysentery syndrome (a …

The T cell response to Shigella, the causative agent of bacillary dysentery, remains poorly
understood. Using a murine model of infection, we report that Shigella flexneri primes …

Shigellosis is one of the leading causes of diarrhea worldwide with more than 130 million
cases annually. Hence, the research of an effective vaccine is still a priority. Unfortunately, a …