Sexual development in Plasmodium parasites: knowing when it's time to commit

GA Josling, M Llinás - Nature Reviews Microbiology, 2015 - nature.com
Malaria is a devastating infectious disease that is caused by blood-borne apicomplexan
parasites of the genus Plasmodium. These pathogens have a complex lifecycle, which …

Division and transmission: malaria parasite development in the mosquito

DS Guttery, M Zeeshan, DJP Ferguson… - Annual Review of …, 2022 - annualreviews.org
The malaria parasite life cycle alternates between two hosts: a vertebrate and the female
Anopheles mosquito vector. Cell division, proliferation, and invasion are essential for …

UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein–DNA interactions

MA Hume, LA Barrera, SS Gisselbrecht… - Nucleic acids …, 2015 - academic.oup.com
Abstract The Universal PBM Resource for Oligonucleotide Binding Evaluation (UniPROBE)
serves as a convenient source of information on published data generated using universal …

Life cycle progression and sexual development of the apicomplexan parasite Cryptosporidium parvum

J Tandel, ED English, A Sateriale, JA Gullicksrud… - Nature …, 2019 - nature.com
The apicomplexan parasite Cryptosporidium is a leading global cause of severe diarrhoeal
disease and an important contributor to early childhood mortality. Currently, there are no …

A knockout screen of ApiAP2 genes reveals networks of interacting transcriptional regulators controlling the Plasmodium life cycle

K Modrzynska, C Pfander, L Chappell, L Yu, C Suarez… - Cell host & …, 2017 - cell.com
A family of apicomplexa-specific proteins containing AP2 DNA-binding domains (ApiAP2s)
was identified in malaria parasites. This family includes sequence-specific transcription …

ApiAP2 transcription factors in apicomplexan parasites

MD Jeninga, JE Quinn, M Petter - Pathogens, 2019 - mdpi.com
Apicomplexan parasites are protozoan organisms that are characterised by complex life
cycles and they include medically important species, such as the malaria parasite …

The modular circuitry of apicomplexan cell division plasticity

MJ Gubbels, I Coppens, K Zarringhalam… - Frontiers in Cellular …, 2021 - frontiersin.org
The close-knit group of apicomplexan parasites displays a wide variety of cell division
modes, which differ between parasites as well as between different life stages within a …

Genetic ablation of a female-specific apetala 2 transcription factor blocks oocyst shedding in Cryptosporidium parvum

J Tandel, KA Walzer, JH Byerly, B Pinkston, DP Beiting… - Mbio, 2023 - Am Soc Microbiol
The apicomplexan parasite Cryptosporidium is a leading global cause of diarrheal disease,
and the infection poses a particularly grave threat to young children and those with …

Opposing Transcriptional Mechanisms Regulate Toxoplasma Development

DP Hong, JB Radke, MW White - Msphere, 2017 - Am Soc Microbiol
The Toxoplasma biology that underlies human chronic infection is developmental
conversion of the acute tachyzoite stage into the latent bradyzoite stage. We investigated the …

Cell cycle-regulated ApiAP2s and parasite development: the Toxoplasma paradigm

K Zarringhalam, S Ye, J Lou, Y Rezvani… - Current Opinion in …, 2023 - Elsevier
Highlights•AP2 factors are the major gene expression drivers of the T. gondii cell cycle.•AP2
factors can act as activators or repressors in complex with other players.•A distinct, shared …