Microglia in central nervous system inflammation and multiple sclerosis pathology

S Voet, M Prinz, G van Loo - Trends in molecular medicine, 2019 - cell.com
Microglia are the resident macrophages of the central nervous system (CNS). They have
important physiological functions in maintaining tissue homeostasis but also contribute to …

Neuroimmunology of traumatic brain injury: time for a paradigm shift

YN Jassam, S Izzy, M Whalen, DB McGavern… - Neuron, 2017 - cell.com
Traumatic brain injury (TBI) is a leading cause of morbidity and disability, with a
considerable socioeconomic burden. Heterogeneity of pathoanatomical subtypes and …

Dynamic changes in glioma macrophage populations after radiotherapy reveal CSF-1R inhibition as a strategy to overcome resistance

L Akkari, RL Bowman, J Tessier, F Klemm… - Science translational …, 2020 - science.org
Tumor-associated macrophages (TAMs) and microglia (MG) are potent regulators of glioma
development and progression. However, the dynamic alterations of distinct TAM populations …

Novel Hexb-based tools for studying microglia in the CNS

T Masuda, L Amann, R Sankowski, O Staszewski… - Nature …, 2020 - nature.com
Microglia and central nervous system (CNS)-associated macrophages (CAMs), such as
perivascular and meningeal macrophages, are implicated in virtually all diseases of the …

Microglia in physiology and disease

SA Wolf, H Boddeke… - Annual review of …, 2017 - annualreviews.org
As the immune-competent cells of the brain, microglia play an increasingly important role in
maintaining normal brain function. They invade the brain early in development, transform …

Origin, fate and dynamics of macrophages at central nervous system interfaces

T Goldmann, P Wieghofer, MJC Jordão, F Prutek… - Nature …, 2016 - nature.com
Perivascular, subdural meningeal and choroid plexus macrophages are non-parenchymal
macrophages that mediate immune responses at brain boundaries. Although the origin of …

A new fate mapping system reveals context-dependent random or clonal expansion of microglia

TL Tay, D Mai, J Dautzenberg, F Fernández-Klett… - Nature …, 2017 - nature.com
Microglia constitute a highly specialized network of tissue-resident immune cells that is
important for the control of tissue homeostasis and the resolution of diseases of the CNS …

The biphasic function of microglia in ischemic stroke

Y Ma, J Wang, Y Wang, GY Yang - Progress in neurobiology, 2017 - Elsevier
Microglia are brain resident macrophages originated from primitive progenitor cells in the
yolk sac. Microglia can be activated within hours and recruited to the lesion site …

[HTML][HTML] Glia–neuron interactions in the mammalian retina

E Vecino, FD Rodriguez, N Ruzafa, X Pereiro… - Progress in retinal and …, 2016 - Elsevier
The mammalian retina provides an excellent opportunity to study glia–neuron interactions
and the interactions of glia with blood vessels. Three main types of glial cells are found in …

Microglia across the lifespan: from origin to function in brain development, plasticity and cognition

TL Tay, JC Savage, CW Hui, K Bisht… - The Journal of …, 2017 - Wiley Online Library
Microglia are the only immune cells that permanently reside in the central nervous system
(CNS) alongside neurons and other types of glial cells. The past decade has witnessed a …