Biological activity and pharmacological application of pectic polysaccharides: A review

ST Minzanova, VF Mironov, DM Arkhipova… - Polymers, 2018 - mdpi.com
Pectin is a polymer with a core of alternating α-1, 4-linked d-galacturonic acid and α-1, 2-l-
rhamnose units, as well as a variety of neutral sugars such as arabinose, galactose, and …

pH-Responsive carriers for oral drug delivery: challenges and opportunities of current platforms

L Liu, WD Yao, YF Rao, XY Lu, JQ Gao - Drug Delivery, 2017 - Taylor & Francis
Oral administration is a desirable alternative of parenteral administration due to the
convenience and increased compliance to patients, especially for chronic diseases that …

Emerging micro-and nanotechnology based synthetic approaches for insulin delivery

R Mo, T Jiang, J Di, W Tai, Z Gu - Chemical society reviews, 2014 - pubs.rsc.org
Insulin is essential for type 1 and advanced type 2 diabetics to maintain blood glucose levels
and prolong lives. The traditional administration requires frequent subcutaneous insulin …

Hydrogels in emerging technologies for type 1 diabetes

S Fuchs, AU Ernst, LH Wang, K Shariati… - Chemical …, 2020 - ACS Publications
Type 1 diabetes therapies that afford tighter glycemic control in a more manageable and
painless manner for patients has remained a central focus of next-generation diabetes …

Potential of insulin nanoparticle formulations for oral delivery and diabetes treatment

CY Wong, H Al-Salami, CR Dass - Journal of controlled release, 2017 - Elsevier
Nanoparticles have demonstrated significant advancements in potential oral delivery of
insulin. In this publication, we review the current status of polymeric, inorganic and solid-lipid …

Therapeutic applications of hydrogels in oral drug delivery

LA Sharpe, AM Daily, SD Horava… - Expert opinion on drug …, 2014 - Taylor & Francis
Introduction: Oral delivery of therapeutics, particularly protein-based pharmaceutics, is of
great interest for safe and controlled drug delivery for patients. Hydrogels offer excellent …

Nanoparticle delivery systems in the treatment of diabetes complications

EB Souto, SB Souto, JR Campos, P Severino… - Molecules, 2019 - mdpi.com
Diabetes mellitus, an incurable metabolic disease, is characterized by changes in the
homeostasis of blood sugar levels, being the subcutaneous injection of insulin the first line …

Efficient mucus permeation and tight junction opening by dissociable “mucus-inert” agent coated trimethyl chitosan nanoparticles for oral insulin delivery

M Liu, J Zhang, X Zhu, W Shan, L Li, J Zhong… - Journal of controlled …, 2016 - Elsevier
Oral administration of protein drugs is greatly impeded by the lack of drug carriers that can
efficiently overcome the absorption barriers of mucosa tissue, which consists of not only …

Biomimetic platelet nanomotors for site-specific thrombolysis and ischemic injury alleviation

YT Chen, CH Liu, WY Pan, PR Jheng… - … applied materials & …, 2023 - ACS Publications
Due to the mortality associated with thrombosis and its high recurrence rate, there is a need
to investigate antithrombotic approaches. Noninvasive site-specific thrombolysis is a current …

Anti-diabetic effect of citrus pectin in diabetic rats and potential mechanism via PI3K/Akt signaling pathway

Y Liu, M Dong, Z Yang, S Pan - International Journal of Biological …, 2016 - Elsevier
This study was performed to investigate the anti-diabetic effect of citrus pectin in type 2
diabetic rats and its potential mechanism of action. The results showed that fasting blood …