The cytoskeleton plays an integral role in maintaining the integrity of epithelial cells.
Epithelial cells primarily employ cytokeratin in their cytoskeleton, whereas mesenchymal …

Abstract Protein phosphatase 2A (PP2A) plays a critical multi-faceted role in the regulation
of the cell cycle. It is known to dephosphorylate over 300 substrates involved in the cell …

Vimentin, a major constituent of the intermediate filament family of proteins, is ubiquitously
expressed in normal mesenchymal cells and is known to maintain cellular integrity and …

Protein Phosphatase 2A (PP2A) is an important and ubiquitously expressed serine
threonine phosphatase and regulates the function by dephosphorylating many critical …

Protein phosphatase 2A (PP2A) comprises a family of serine/threonine phosphatases,
minimally containing a well conserved catalytic subunit, the activity of which is highly …

The serine/threonine protein phosphatase (PP2A) is a trimeric holoenzyme that plays an
integral role in the regulation of a number of major signaling pathways whose deregulation …

Vimentin is a widely expressed intermediate filament protein thought to be involved mainly
in structural processes, such as wound healing. We now demonstrate that activated human …

The assembly of intermediate filament (IF) arrays involves the recruitment of a complex set of
cell-type-specific IF-associated proteins. Some of them are integral membrane proteins …

Since abnormal tau phosphorylation may play a role in neurofibrillary tangle (NFT) formation
in aging and Alzheimer's disease (AD), we probed the distribution and abundance of protein …

Dynamic phosphorylation and dephosphorylation of proteins are fundamental mechanisms
utilized by cells to transduce signals. Whereas transduction by protein kinases has been a …