[HTML][HTML] Genetic polymorphism of metabolic enzymes P450 (CYP) as a susceptibility factor for drug response, toxicity, and cancer risk
The polymorphic P450 (CYP) enzyme superfamily is the most important system involved in
the biotransformation of many endogenous and exogenous substances including drugs …
the biotransformation of many endogenous and exogenous substances including drugs …
Gene–environment interactions in heavy metal and pesticide carcinogenesis
Cancer is a complex disease involving a sequence of gene–environment interactions.
Lifestyle, genetics, dietary factors, and environmental pollutants can increase the risk of …
Lifestyle, genetics, dietary factors, and environmental pollutants can increase the risk of …
[HTML][HTML] Phase I metabolic genes and risk of lung cancer: multiple polymorphisms and mRNA expression
Polymorphisms in genes coding for enzymes that activate tobacco lung carcinogens may
generate inter-individual differences in lung cancer risk. Previous studies had limited sample …
generate inter-individual differences in lung cancer risk. Previous studies had limited sample …
[HTML][HTML] Genetic polymorphisms of the human cytochrome P450 1A1 (CYP1A1) and cervical cancer susceptibility among Northeast Thai women
M Wongpratate, W Settheetham-Ishida… - Asian Pacific journal …, 2020 - ncbi.nlm.nih.gov
Background: CYP1A1 is an enzyme in phase I of the cytochrome P450 (CYP) superfamily,
and plays a key role in detoxification of carcinogens. Host genetic predisposition in the …
and plays a key role in detoxification of carcinogens. Host genetic predisposition in the …
Lung cancer risk in relation to nicotinic acetylcholine receptor, CYP2A6 and CYP1A1 genotypes in the Bangladeshi population
BACKGROUND: CYP1A1, CYP2A6 and CHRNA5 are biologically plausible genes as risk
factors for lung cancer but no studies have been reported in the Bangladeshi population …
factors for lung cancer but no studies have been reported in the Bangladeshi population …
A genome-wide gene–environment interaction analysis for tobacco smoke and lung cancer susceptibility
Tobacco smoke is the major environmental risk factor underlying lung carcinogenesis.
However, approximately one-tenth smokers develop lung cancer in their lifetime indicating …
However, approximately one-tenth smokers develop lung cancer in their lifetime indicating …
Evidence for increased cytochrome P450 1A1 expression in blood lymphocytes of lung cancer patients
To develop blood lymphocyte cytochrome P450 1A1 (CYP1A1) expression as a surrogate
for monitoring tissue expression for polycyclic aromatic hydrocarbon (PAH) induced toxicity …
for monitoring tissue expression for polycyclic aromatic hydrocarbon (PAH) induced toxicity …
Genetic association study of CYP1A1 polymorphisms identifies risk haplotypes in nonsmall cell lung cancer
CM Wright, JE Larsen, ML Colosimo… - European …, 2010 - Eur Respiratory Soc
Lung cancer remains a leading cause of disease globally, with smoking being the largest
single cause. Phase I enzymes, including cytochrome P450, family 1, subfamily A …
single cause. Phase I enzymes, including cytochrome P450, family 1, subfamily A …
[HTML][HTML] CYP1A1 MspI and exon7 gene polymorphisms and lung cancer risk: an updated meta-analysis and review
P Zhan, Q Wang, Q Qian, SZ Wei, LK Yu - Journal of Experimental & …, 2011 - Springer
Background Many studies have examined the association between the CYP1A1 MspI and
exon 7 gene polymorphisms and lung cancer risk in various populations, but their results …
exon 7 gene polymorphisms and lung cancer risk in various populations, but their results …
Association between CYP2E1 genetic polymorphisms and lung cancer risk: a meta-analysis
Y Wang, H Yang, L Li, H Wang, C Zhang, G Yin… - European Journal of …, 2010 - Elsevier
Genetic variations in metabolic genes are thought to modify the metabolic process of
carcinogens and are suggested to be related to cancer risk. However, epidemiological …
carcinogens and are suggested to be related to cancer risk. However, epidemiological …