Alzheimer's Disease (AD) is a devastating neurodegenerative disorder of the brain, clinically
characterised by cognitive deficits that gradually worsen over time. There is, at present, no …

Alzheimer's disease (AD) is a neurodegenerative disorder with neuronal and synaptic
losses due to the accumulation of toxic amyloid β (Αβ) peptide oligomers, plaques, and …

Injury of oligodendrocytes (OLs) induces demyelination, and patients with
neurodegenerative diseases exhibit demyelination concomitantly with neurological deficit …

Severe cognitive decline is a hallmark of Alzheimer's disease (AD). In addition to gray matter
loss, significant white matter pathology has been identified in AD patients. Here, we …

The cholinergic system has a crucial role to play in visual function. Although cholinergic
drugs have been a focus of attention as glaucoma medications for reducing eye pressure …

Axonal degeneration is central to clinical disability and disease progression in multiple
sclerosis (MS). Myeloid cells such as brain-resident microglia and blood-borne monocytes …

Neuroinflammation relying on the inflammatory responses of glial cells has emerged as an
impactful component of the multifactorial etiology of neurodegeneration in glaucoma. It has …

The death of retinal ganglion cells (RGCs) is a key factor in the pathophysiology of all types
of glaucoma, but the mechanism of pathogenesis of glaucoma remains unclear. RGCs are a …

Glaucoma is a chronic neurodegenerative disease characterized by apoptosis of retinal
ganglion cell (RGC) somas, degeneration of axons, and loss of synapses at dendrites and …

A number of substances released by the brain under physiological and pathological
conditions exert effects on other organs. In turn, substances produced primarily by organs …