Role of ceramides in the pathogenesis of diabetes mellitus and its complications
Diabetes mellitus (DM) is a systemic metabolic disease that affects 463 million adults
worldwide and is a leading cause of cardiovascular disease, blindness, nephropathy …
worldwide and is a leading cause of cardiovascular disease, blindness, nephropathy …
Functions of sphingolipids in pathogenesis during host–pathogen interactions
J Wang, YL Chen, YK Li, DK Chen, JF He… - Frontiers in …, 2021 - frontiersin.org
Sphingolipids are a class of membrane lipids that serve as vital structural and signaling
bioactive molecules in organisms ranging from yeast to animals. Recent studies have …
bioactive molecules in organisms ranging from yeast to animals. Recent studies have …
Human bronchial epithelial cells exposed in vitro to cigarette smoke at the air-liquid interface resemble bronchial epithelium from human smokers
C Mathis, C Poussin, D Weisensee… - … of Physiology-Lung …, 2013 - journals.physiology.org
Organotypic culture of human primary bronchial epithelial cells is a useful in vitro system to
study normal biological processes and lung disease mechanisms, to develop new therapies …
study normal biological processes and lung disease mechanisms, to develop new therapies …
Inflammation: A Double-Edged Sword in the Response to Pseudomonas aeruginosa Infection
CK Lin, BI Kazmierczak - Journal of innate immunity, 2017 - karger.com
The Gram-negative opportunistic pathogen Pseudomonas aeruginosa exploits failures of
barrier defense and innate immunity to cause acute infections at a range of anatomic sites …
barrier defense and innate immunity to cause acute infections at a range of anatomic sites …
Microbial, host and xenobiotic diversity in the cystic fibrosis sputum metabolome
Cystic fibrosis (CF) lungs are filled with thick mucus that obstructs airways and facilitates
chronic infections. Pseudomonas aeruginosa is a significant pathogen of this disease that …
chronic infections. Pseudomonas aeruginosa is a significant pathogen of this disease that …
Tracking the immunopathological response to Pseudomonas aeruginosa during respiratory infections
Repeated cycles of infections, caused mainly by Pseudomonas aeruginosa, combined with
a robust host immune response and tissue injury, determine the course and outcome of …
a robust host immune response and tissue injury, determine the course and outcome of …
Role of cystic fibrosis bronchial epithelium in neutrophil chemotaxis
A hallmark of cystic fibrosis (CF) chronic respiratory disease is an extensive neutrophil
infiltrate in the mucosa filling the bronchial lumen, starting early in life for CF infants. The …
infiltrate in the mucosa filling the bronchial lumen, starting early in life for CF infants. The …
Corilagin is a potent inhibitor of NF-kappaB activity and downregulates TNF-alpha induced expression of IL-8 gene in cystic fibrosis IB3-1 cells
Corilagin (beta-1-O-galloyl-3, 6-(R)-hexahydroxydiphenoyl-d-glucose), a gallotannin
identified in several plants, including Phyllanthus urinaria, has been shown to exhibit …
identified in several plants, including Phyllanthus urinaria, has been shown to exhibit …
Involvement of ceramides in non-alcoholic fatty liver disease (Nafld) atherosclerosis (ats) development: Mechanisms and therapeutic targets
Non-alcoholic fatty liver disease (NAFLD) and atherosclerosis (ATS) are worldwide known
diseases with increased incidence and prevalence. These two are driven and are …
diseases with increased incidence and prevalence. These two are driven and are …
Synthesis and therapeutic applications of iminosugars in cystic fibrosis
Iminosugars are sugar analogues endowed with a high pharmacological potential. The wide
range of biological activities exhibited by these glycomimetics associated with their excellent …
range of biological activities exhibited by these glycomimetics associated with their excellent …