Mechanisms of action of coffee bioactive compounds–A key to unveil the coffee paradox

F Machado, MA Coimbra, MD Castillo… - Critical reviews in …, 2024 - Taylor & Francis
The knowledge of the relationship between the chemical structure of food components with
their mechanisms of action is crucial for the understanding of diet health benefits. This …

A comprehensive review of furan in foods: From dietary exposures and in vivo metabolism to mitigation measures

Y Zhang, Y Zhang - … Reviews in Food Science and Food Safety, 2023 - Wiley Online Library
Furan is a thermal food processing contaminant that is ubiquitous in various food products
such as coffee, canned and jarred foods, and cereals. A comprehensive summary of …

Risks for public health related to the presence of furan and methylfurans in food

EFSA Panel on Contaminants in the Food Chain … - EFSA …, 2017 - Wiley Online Library
Abstract The European Commission asked EFSA for a scientific evaluation on the risk to
human health of the presence of furan and methylfurans (2‐methylfuran, 3‐methylfuran and …

Cytochrome P450–mediated metabolic activation of diosbulbin B

D Lin, C Li, Y Peng, H Gao, J Zheng - Drug metabolism and disposition, 2014 - ASPET
Diosbulbin B (DIOB), a furan-containing diterpenoid lactone, is the most abundant
component of Dioscorea bulbifera L.(DB), a traditional Chinese medicine herb …

Metabolic activation of 2-methylfuran to acetylacrolein and its reactivity toward cellular proteins

V Schäfer, S Stegmüller, H Becker… - Chemical Research in …, 2024 - ACS Publications
2-Methylfuran (2-MF) is a process-related contaminant found primarily in heat-treated foods,
such as coffee or canned food. The oxidative metabolic activation of 2-MF is supposed to …

Review on Furan as a Food Processing Contaminant: Identifying Research Progress and Technical Challenges for Future Research

Z Batool, JH Chen, B Liu, F Chen… - Journal of Agricultural …, 2023 - ACS Publications
A wide range of food processing contaminants (FPCs) are usually formed while thermal
processing of food products. Furan is a highly volatile compound among FPCs and could be …

Protective role of garlic oil against oxidative damage induced by furan exposure from weaning through adulthood in adult rat testis

G El-Akabawy, NM El-Sherif - Acta histochemica, 2016 - Elsevier
Furan is produced in a wide variety of heat-treated foods via thermal degradation. Furan
contamination is found to be relatively high in processed baby foods, cereal products, fruits …

Effects of GSTT1 Genotype on the Detoxification of 1,3-Butadiene Derived Diepoxide and Formation of Promutagenic DNA–DNA Cross-Links in Human Hapmap Cell …

G Boysen, R Arora, A Degner, KR Vevang… - Chemical research in …, 2020 - ACS Publications
Smoking is a leading cause of lung cancer, accounting for 81% of lung cancer cases.
Tobacco smoke contains over 5000 compounds, of which more than 70 have been …

Inhaled furan selectively damages club cells in lungs of A/J mice

AF Tǎbǎran, MG O'Sullivan… - Toxicologic …, 2019 - journals.sagepub.com
Furan, a possible human carcinogen, is a product of incomplete combustion and is present
in cigarette smoke, engine exhaust, and processed food. Oral administration induces liver …

Applications of Adductomics in Chemically Induced Adverse Outcomes and Major Emphasis on DNA Adductomics: A Pathbreaking Tool in Biomedical Research

T Behl, M Rachamalla, A Najda, A Sehgal… - International journal of …, 2021 - mdpi.com
Adductomics novel and emerging discipline in the toxicological research emphasizes on
adducts formed by reactive chemical agents with biological molecules in living organisms …