Cardiovascular disease (CVD) is a major global cause of mortality, which has prompted
numerous studies seeking to reduce the risk of heart failure and sudden cardiac death …

Aim Chronic heart failure (CHF) is often linked to liver malfunction and systemic endothelial
dysfunction. However, whether cardio‐hepatic interactions in heart failure involve …

Lifestyle has been linked to the incidence of heart failure, but the underlying biological
mechanisms remain unclear. Using the metabolomic, lifestyle, and heart failure data of the …

Exercise intolerance, a hallmark of heart failure with preserved ejection fraction (HFpEF)
exacerbated by obesity, involves unclear mechanisms related to skeletal muscle …

Background Although advanced heart failure (HF) is a clinically documented risk factor for
vascular cognitive impairment, the occurrence and pathomechanisms of vascular cognitive …

We evaluated the influence of aerobic exercise on cardiac remodelling during the transition
from compensated left ventricular (LV) hypertrophy to clinical heart failure in aortic stenosis …

Age represents a major risk factor in heart failure (HF). However, the mechanisms linking
ageing and HF are not clear. We aimed to identify the functional, morphological and …

Muscle atrophy is a common complication of heart failure. At present, there is no specific
treatment to reverse the course of muscle atrophy. Exercise training, due to the safety and …

Angiotensin-converting enzyme inhibition (ACE-I) and physical activity favorably modulate
the ACE/ACE-2 balance. However, it is not clear whether physical activity and ACE-I could …

The goal of this study was to assess the alterations in left ventricle (LV) blood flow velocity
patterns in relation to progressive impairment of cardiac function in the course of heart …