The biology and function of extracellular vesicles in immune response and immunity

R Kalluri - Immunity, 2024 - cell.com
Extracellular vesicles (EVs), such as ectosomes and exosomes, contain DNA, RNA, proteins
and are encased in a phospholipid bilayer. EVs provide intralumenal cargo for delivery into …

[HTML][HTML] Small extracellular vesicles: Non-negligible vesicles in tumor progression, diagnosis, and therapy

X Zhou, Y Jia, C Mao, S Liu - Cancer Letters, 2024 - Elsevier
Small extracellular vesicles (sEVs) such as exosomes are nanoscale membranous particles
(< 200 nm) that have emerged as crucial targets for liquid biopsy and as promising drug …

Tumor-derived small extracellular vesicles in cancer invasion and metastasis: molecular mechanisms, and clinical significance

C Zhang, C Qin, S Dewanjee, H Bhattacharya… - Molecular Cancer, 2024 - Springer
The production and release of tumor-derived small extracellular vesicles (TDSEVs) from
cancerous cells play a pivotal role in the propagation of cancer, through genetic and …

The Role of Exosome-Derived MicroRNA on Lung Cancer Metastasis Progression

I Martinez-Espinosa, JA Serrato, B Ortiz-Quintero - Biomolecules, 2023 - mdpi.com
The high mortality from lung cancer is mainly attributed to the presence of metastases at the
time of diagnosis. Despite being the leading cause of lung cancer death, the underlying …

[HTML][HTML] Hypoxia-regulated exosomes mediate M2 macrophage polarization and promote metastasis in chondrosarcoma

SM Hou, CY Lin, YC Fong, CH Tang - Aging (Albany NY), 2023 - ncbi.nlm.nih.gov
Chondrosarcoma is a primary malignant bone tumor. Traditional therapy is not very effective,
and it is prone to metastasis in the late stage. The tumor microenvironment (TME) plays a …

[HTML][HTML] Extracellular vesicles: Emerging mediators of cell communication in gastrointestinal cancers exhibiting metabolic abnormalities

G Pourali, N Zafari, H Fiuji, J Batra, E Nazari… - Cytokine & Growth …, 2023 - Elsevier
There is a complex interaction between pro-tumoural and anti-tumoural networks in the
tumour microenvironment (TME). Throughout tumourigenesis, communication between …

Long non-coding RNAs in colorectal cancer: navigating the intersections of immunity, intercellular communication, and therapeutic potential

NK Shakhpazyan, LM Mikhaleva, AL Bedzhanyan… - Biomedicines, 2023 - mdpi.com
This comprehensive review elucidates the intricate roles of long non-coding RNAs
(lncRNAs) within the colorectal cancer (CRC) microenvironment, intersecting the domains of …

Unraveling the Multifaceted Roles of Extracellular Vesicles: Insights into Biology, Pharmacology, and Pharmaceutical Applications for Drug Delivery

A Al-Jipouri, À Eritja, M Bozic - International Journal of Molecular …, 2023 - mdpi.com
Extracellular vesicles (EVs) are nanoparticles released from various cell types that have
emerged as powerful new therapeutic option for a variety of diseases. EVs are involved in …

Single-cell transcriptomics in ovarian cancer identify a metastasis-associated cell cluster overexpressed RAB13

J Guo, X Han, J Li, Z Li, J Yi, Y Gao, X Zhao… - Journal of Translational …, 2023 - Springer
Background Metastasis, the leading cause of cancer-related death in patients diagnosed
with ovarian cancer (OC), is a complex process that involves multiple biological effects. With …

Dual effects of radiotherapy on tumor microenvironment and its contribution towards the development of resistance to immunotherapy in gastrointestinal and thoracic …

D Zhao, Y Mo, ME Neganova… - Frontiers in Cell and …, 2023 - frontiersin.org
Successful clinical methods for tumor elimination include a combination of surgical
resection, radiotherapy, and chemotherapy. Radiotherapy is one of the crucial components …