ATP and cancer immunosurveillance
While intracellular adenosine triphosphate (ATP) occupies a key position in the bioenergetic
metabolism of all the cellular compartments that form the tumor microenvironment (TME) …
metabolism of all the cellular compartments that form the tumor microenvironment (TME) …
Mechanisms of ATP release by inflammatory cells
Extracellular nucleotides (eg, ATP, ADP, UTP, UDP) released by inflammatory cells interact
with specific purinergic P2 type receptors to modulate their recruitment and activation. The …
with specific purinergic P2 type receptors to modulate their recruitment and activation. The …
Purine release, metabolism, and signaling in the inflammatory response
ATP, NAD+, and nucleic acids are abundant purines that, in addition to having critical
intracellular functions, have evolved extracellular roles as danger signals released in …
intracellular functions, have evolved extracellular roles as danger signals released in …
ATP release through pannexon channels
G Dahl - Philosophical Transactions of the Royal Society …, 2015 - royalsocietypublishing.org
Extracellular adenosine triphosphate (ATP) serves as a signal for diverse physiological
functions, including spread of calcium waves between astrocytes, control of vascular oxygen …
functions, including spread of calcium waves between astrocytes, control of vascular oxygen …
[HTML][HTML] Differentiating connexin hemichannels and pannexin channels in cellular ATP release
AW Lohman, BE Isakson - FEBS letters, 2014 - Elsevier
Adenosine triphosphate (ATP) plays a fundamental role in cellular communication, with its
extracellular accumulation triggering purinergic signaling cascades in a diversity of cell …
extracellular accumulation triggering purinergic signaling cascades in a diversity of cell …
Into rather unexplored terrain—Transcellular transport across the blood–brain barrier
M De Bock, V Van Haver, RE Vandenbroucke… - Glia, 2016 - Wiley Online Library
Efficient neuronal signaling in the central nervous system strictly depends on a well‐
balanced microenvironment around glial cells, synapses, and axons. Unique features of the …
balanced microenvironment around glial cells, synapses, and axons. Unique features of the …
Pannexin-1 channels contribute to seizure generation in human epileptic brain tissue and in a mouse model of epilepsy
Epilepsies are characterized by recurrent seizures, which disrupt normal brain function.
Alterations in neuronal excitability and excitation-inhibition balance have been shown to …
Alterations in neuronal excitability and excitation-inhibition balance have been shown to …
A molecular signature in the pannexin1 intracellular loop confers channel activation by the α1 adrenoreceptor in smooth muscle cells
Both purinergic signaling through nucleotides such as ATP (adenosine 5′-triphosphate)
and noradrenergic signaling through molecules such as norepinephrine regulate vascular …
and noradrenergic signaling through molecules such as norepinephrine regulate vascular …
The pannexins: past and present
SR Bond, CC Naus - Frontiers in physiology, 2014 - frontiersin.org
The pannexins (Panxs) are a family of chordate proteins homologous to the invertebrate gap
junction forming proteins named innexins. Three distinct Panx paralogs (Panx1, Panx2, and …
junction forming proteins named innexins. Three distinct Panx paralogs (Panx1, Panx2, and …
Could experimental inflammation provide better understanding of migraines?
Migraines constitute a common neurological and headache disorder affecting around 15%
of the world's population. In addition to other mechanisms, neurogenic neuroinflammation …
of the world's population. In addition to other mechanisms, neurogenic neuroinflammation …