Bacteria of the genus Legionella are natural pathogens of amoebae that can cause a severe
pneumonia in humans called Legionnaires' Disease. Human disease results from inhalation …

To prevail in the interaction with eukaryotic hosts, many bacterial pathogens use protein
secretion systems to release virulence factors at the host–pathogen interface and/or deliver …

The intracellular pathogen Legionella pneumophila delivers more than 330 effectors into
host cells by its Dot/Icm secretion system. Those effectors direct the biogenesis of the …

ADP-ribosylation is a reversible post-translational modification involved in various cellular
activities. Removal of ADP-ribosylation requires (ADP-ribosyl) hydrolases, with …

Pathogenic species of Legionella can infect human alveolar macrophages through
Legionella-containing aerosols to cause a disease called Legionellosis, which has two …

Legionella pneumophila utilizes the Dot/Icm type IVB secretion system to deliver hundreds
of effector proteins inside eukaryotic cells to ensure intracellular replication. Our …

Adenosine diphosphate (ADP) ribosylation is a reversible posttranslational modification
involved in the regulation of numerous cellular processes. Prototype ADP …

The pathogenic Legionella bacteria are notorious for delivering numerous effector proteins
into the host cell with the aim of disturbing and hijacking cellular processes for their benefit …

Legionella pneumophila is a Gram-negative bacterium ubiquitously present in freshwater
environments and causes a serious type of pneumonia called Legionnaires' disease. During …

Work over the past two decades clearly defined a significant role of glycosyltransferase
effectors in the infection strategy of the Gram-negative, respiratory pathogen Legionella …