Large, elastic arteries are composed of cells and a specialized extracellular matrix that
provides reversible elasticity and strength. Elastin is the matrix protein responsible for this …

As the primary component of elastic fibers, elastin plays an important role in maintaining the
elasticity and tensile ability of cardiovascular, pulmonary and many other tissues and …

Williams syndrome (WS) is a relatively rare microdeletion disorder that occurs in as many as
1: 7,500 individuals. WS arises due to the mispairing of low-copy DNA repetitive elements at …

Hypertension is often characterised by impaired vasodilation involving dysfunction of
multiple vasodilatory mechanisms. ω‐3 polyunsaturated fatty acids (PUFAs) …

Despite much effort, synthetic small diameter vascular grafts still face limited success due to
vascular wall thickening known as intimal hyperplasia (IH). Compliance mismatch between …

Cardiovascular abnormalities are a major determining factor in the clinical picture and
trajectory of patients with Williams syndrome. Advances in surgical techniques, medical …

Elastic fibers provide recoil to tissues that undergo repeated deformation, such as blood
vessels, lungs and skin. Composed of elastin and its accessory proteins, the fibers are …

The Cardiovascular Continuum describes a sequence of events from cardiovascular risk
factors to end‐stage heart disease. It includes conventional pathologies affecting …

Damage accumulation in long-living macromolecules (especially extracellular matrix (ECM)
proteins, nuclear pore complex (NPC) proteins, and histones) is a missing hallmark of aging …

Although social jetlag (SJL) is generally considered a chronic condition, even acute SJL
may have unfavorable effects on the cardiovascular system. We focused on the acute effects …