Treatable traits models of care

VM McDonald, AE Holland - Respirology, 2024 - Wiley Online Library
Treatable traits is a personalized approach to the management of respiratory disease. The
approach involves a multidimensional assessment to understand the traits present in …

Prioritizing research challenges and funding for allergy and asthma and the need for translational research—The European Strategic Forum on Allergic Diseases

I Agache, I Annesi‐Maesano, A Bonertz, F Branca… - Allergy, 2019 - Wiley Online Library
Abstract The European Academy of Allergy and Clinical Immunology (EAACI) organized the
first European Strategic Forum on Allergic Diseases and Asthma. The main aim was to bring …

Identification of asthma phenotypes based on extrapulmonary treatable traits

PD Freitas, RF Xavier, VM McDonald… - European …, 2021 - Eur Respiratory Soc
Asthma is a heterogeneous and complex disease, and a description of asthma phenotypes
based on extrapulmonary treatable traits has not been previously reported. The objective of …

[HTML][HTML] Tezepelumab improves patient-reported outcomes in patients with severe, uncontrolled asthma in PATHWAY

J Corren, EG Gil, JM Griffiths, JR Parnes… - Annals of Allergy …, 2021 - Elsevier
Background Patients with severe, uncontrolled asthma experience frequent exacerbations
and hospitalization, leading to poor health-related quality of life. In the phase 2b PATHWAY …

What matters to people with severe asthma? Exploring add-on asthma medication and outcomes of importance

VL Clark, PG Gibson, VM McDonald - ERJ Open Research, 2021 - Eur Respiratory Soc
There is an increasing number of new therapies for severe asthma; however, what outcomes
people with severe asthma would like improved and what aspects they prioritise in new …

Effect of patient inhalation profile and airway structure on drug deposition in image-based models with particle-particle interactions

J Williams, J Kolehmainen, S Cunningham… - International Journal of …, 2022 - Elsevier
For many of the one billion sufferers of respiratory diseases worldwide, managing their
disease with inhalers improves their ability to breathe. Poor disease management and rising …

Effectiveness of interventions targeting treatable traits for the management of obstructive airway diseases: a systematic review and meta-analysis

MR Sarwar, VM McDonald, MJ Abramson… - The Journal of Allergy …, 2022 - Elsevier
Background The management of obstructive airway diseases (OADs) is complex. The
treatable traits (TTs) approach may be an effective strategy for managing OADs. Objective …

Living well with severe asthma

MA Stubbs, VL Clark, VM McDonald - Breathe, 2019 - Eur Respiratory Soc
Living well with severe asthma can be challenging. People with severe asthma can be
refractory to treatment, can experience poor symptom control and are at a heightened risk of …

A review of the unique drug development strategy of indacaterol acetate/glycopyrronium bromide/mometasone furoate: a first-in-class, once-daily, single-inhaler, fixed …

D Brittain, P D'Andrea, E Gruen, M Hosoe, D Jain… - Advances in …, 2022 - Springer
A novel, once-daily (od), fixed-dose combination (FDC) of indacaterol acetate (IND),
glycopyrronium bromide (GLY), and mometasone furoate (MF), delivered by the inhaler …

Severe fatigue in uncontrolled asthma: contributing factors and impact of rehabilitation

KB Fieten, L Ten Have, LN Nijhof… - The Journal of Allergy …, 2024 - Elsevier
Background Fatigue is a major concern for patients with severe asthma. Objective This
observational study aims to assess fatigue severity and associated factors, to explore the …