Surgical procedures are key drivers of pain development and opioid utilization globally.
Various organizations have generated guidance on postoperative pain management …

Disturbances of gastric, intestinal and colonic motor and sensory functions affect a large
proportion of the population worldwide, impair quality of life and cause considerable health …

(AGA) on the medical management of opioid-induced constipation. The guideline was
developed by the AGA Institute's Clinical Guidelines Committee and approved by the AGA …

Gastroparesis (Gp) is a chronic disease characterized by a delayed gastric emptying in the
absence of mechanical obstruction. Although this condition has been reported in the …

Background Opioid-induced bowel dysfunction is a complication of opioid therapy, in which
constipation is the most common and problematic symptom. However, it is frequently under …

Opioids are potent analgesics used for the treatment of acute and chronic pain. Side-effects
are common and among the most bothersome are those associated with opioid-induced …

Background: Pain is one of the most common symptoms in cancer patients. The Japanese
Society for Palliative Medicine (JSPM) first published its clinical guidelines for the …

Background & Aims Opioid-induced constipation (OIC) is a common problem in patients on
chronic opioid therapy for cancer-related and non–cancer-related pain. Approved treatments …

The long-term safety of naldemedine, a peripherally acting m-opioid receptor antagonist,
was evaluated in patients with opioid-induced constipation and chronic noncancer pain in a …

The prescribing and use of opioid analgesics is increasing in Italy owing to a profusion in the
number and types of opioid analgesic products available, and the increasing prevalence of …