Redox biology of respiratory viral infections
Respiratory viruses cause infections of the upper or lower respiratory tract and they are
responsible for the common cold—the most prevalent disease in the world. In many cases …
responsible for the common cold—the most prevalent disease in the world. In many cases …
Studying and modelling dynamic biological processes using time-series gene expression data
Biological processes are often dynamic, thus researchers must monitor their activity at
multiple time points. The most abundant source of information regarding such dynamic …
multiple time points. The most abundant source of information regarding such dynamic …
[HTML][HTML] Time-resolved systems immunology reveals a late juncture linked to fatal COVID-19
COVID-19 exhibits extensive patient-to-patient heterogeneity. To link immune response
variation to disease severity and outcome over time, we longitudinally assessed circulating …
variation to disease severity and outcome over time, we longitudinally assessed circulating …
Upper airway gene expression reveals suppressed immune responses to SARS-CoV-2 compared with other respiratory viruses
SARS-CoV-2 infection is characterized by peak viral load in the upper airway prior to or at
the time of symptom onset, an unusual feature that has enabled widespread transmission of …
the time of symptom onset, an unusual feature that has enabled widespread transmission of …
A diagnostic host response biosignature for COVID-19 from RNA profiling of nasal swabs and blood
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes coronavirus
disease-19 (COVID-19), has emerged as the cause of a global pandemic. We used RNA …
disease-19 (COVID-19), has emerged as the cause of a global pandemic. We used RNA …
Host gene expression classifiers diagnose acute respiratory illness etiology
Acute respiratory infections caused by bacterial or viral pathogens are among the most
common reasons for seeking medical care. Despite improvements in pathogen-based …
common reasons for seeking medical care. Despite improvements in pathogen-based …
Blood transcriptional biomarkers of acute viral infection for detection of pre-symptomatic SARS-CoV-2 infection: a nested, case-control diagnostic accuracy study
Background We hypothesised that host-response biomarkers of viral infections might
contribute to early identification of individuals infected with SARS-CoV-2, which is critical to …
contribute to early identification of individuals infected with SARS-CoV-2, which is critical to …
Animal models for influenza virus pathogenesis, transmission, and immunology
RR Thangavel, NM Bouvier - Journal of immunological methods, 2014 - Elsevier
In humans, infection with an influenza A or B virus manifests typically as an acute and self-
limited upper respiratory tract illness characterized by fever, cough, sore throat, and malaise …
limited upper respiratory tract illness characterized by fever, cough, sore throat, and malaise …
Quantitative set analysis for gene expression: a method to quantify gene set differential expression including gene-gene correlations
Enrichment analysis of gene sets is a popular approach that provides a functional
interpretation of genome-wide expression data. Existing tests are affected by inter-gene …
interpretation of genome-wide expression data. Existing tests are affected by inter-gene …
SARS‐CoV‐2 and other respiratory viruses: what does oxidative stress have to do with it?
IG Fernandes, CA de Brito… - Oxidative medicine …, 2020 - Wiley Online Library
The phenomenon of oxidative stress, characterized as an imbalance in the production of
reactive oxygen species and antioxidant responses, is a well‐known inflammatory …
reactive oxygen species and antioxidant responses, is a well‐known inflammatory …