CD8+ T cells are end effectors of cancer immunity. Most forms of effective cancer
immunotherapy involve CD8+ T cell effector function. Here, we review the current …

The metabolic stress occurring in the tumor microenvironment (TME) hampers T cell anti-
tumor immunity by disturbing T cell metabolic and epigenetic programs. Recent studies are …

Resident memory T cells (TRM) form a distinct type of T memory cells that stably resides in
tissues. TRM form an integral part of the immune sensing network and have the ability to …

CD8+ T cells specific for cancer cells are detected within tumours. However, despite their
presence, tumours progress. The clinical success of immune checkpoint blockade and …

CD8+ tissue resident memory T cells (TRM cells) are essential for immune defence against
pathogens and malignancies, and the molecular processes that lead to TRM cell formation …

Tissue-resident memory T (TRM) cells are non-recirculating cells that exist throughout the
body. Although TRM cells in various organs rely on common transcriptional networks to …

The skin is a complex organ that has devised numerous strategies, such as physical,
chemical, and microbiological barriers, to protect the host from external insults. In addition …

Tissue localization is a critical determinant of T cell immunity. CD8+ T cells are contact-
dependent killers, which requires them to physically be within the tissue of interest to kill …

Non-alcoholic steatohepatitis (NASH) is a leading cause of chronic liver disease that can
progress to liver fibrosis. Recent clinical advance suggests a reversibility of liver fibrosis, but …

The skin is the outermost layer of the body with an extensive surface area of approximately
1· 8 m2, and is the first line of defence against a multitude of external pathogens and …