A living model for obesity and aging research: Caenorhabditis elegans

P Shen, Y Yue, Y Park - Critical reviews in food science and …, 2018 - Taylor & Francis
Caenorhabditis elegans (C. elegans) is a free-living nematode that has been extensively
utilized as an animal model for research involving aging and neurodegenerative diseases …

Using C. elegans to discover therapeutic compounds for ageing-associated neurodegenerative diseases

X Chen, JW Barclay, RD Burgoyne, A Morgan - Chemistry Central Journal, 2015 - Springer
Age-associated neurodegenerative disorders such as Alzheimer's disease are a major
public health challenge, due to the demographic increase in the proportion of older …

Microplastic particles cause intestinal damage and other adverse effects in zebrafish Danio rerio and nematode Caenorhabditis elegans

L Lei, S Wu, S Lu, M Liu, Y Song, Z Fu, H Shi… - Science of the total …, 2018 - Elsevier
Microplastics have been frequently detected in aquatic environments, and there are
increasing concerns about potential effects on biota. In this study, zebrafish Danio rerio and …

Polystyrene (nano) microplastics cause size-dependent neurotoxicity, oxidative damage and other adverse effects in Caenorhabditis elegans

L Lei, M Liu, Y Song, S Lu, J Hu, C Cao, B Xie… - Environmental …, 2018 - pubs.rsc.org
(Nano) microplastics (N/MPs) are emerging contaminants of increasing concern. However,
little is known about the potential toxicity difference between nanoplastics and microplastics …

Antioxidant capacity of flavonoids from Folium Artemisiae Argyi and the molecular mechanism in Caenorhabditis elegans

Q Hu, Z Liu, Y Guo, S Lu, H Du, Y Cao - Journal of ethnopharmacology, 2021 - Elsevier
Abstract Ethnopharmacological relevance Folium Artemisiae Argyi (FAA) is one kind of
Chinese herbal medicine with a long history. It has widespread pharmacological activities …

Anti‐Inflammatory and Antioxidant Properties of Black Mulberry (Morus nigra L.) in a Model of LPS‐Induced Sepsis

K de Pádua Lúcio, ACS Rabelo… - Oxidative medicine …, 2018 - Wiley Online Library
Sepsis is a complex disease and is the cause of many deaths worldwide. Sepsis
pathogenesis involves a dysregulated inflammatory response with consequent production of …

Caenorhabditis elegans as a Model Organism to Evaluate the Antioxidant Effects of Phytochemicals

B Ayuda-Durán, S González-Manzano… - Molecules, 2020 - mdpi.com
The nematode Caenorhabditis elegans was introduced as a model organism in biological
research by Sydney Brenner in the 1970s. Since then, it has been increasingly used for …

Caenorhabditis elegans as a model system for target identification and drug screening against neurodegenerative diseases

L Ma, Y Zhao, Y Chen, B Cheng, A Peng… - European Journal of …, 2018 - Elsevier
Over the past decades, Caenorhabditis elegans (C. elegans) has been widely used as a
model system because of its small size, transparent body, short generation time and lifespan …

Effects of Vegetal Extracts and Metabolites against Oxidative Stress and Associated Diseases: Studies in Caenorhabditis elegans

EY Hernández-Cruz, D Eugenio-Pérez… - ACS …, 2023 - ACS Publications
Oxidative stress is a natural physiological process where the levels of oxidants, such as
reactive oxygen species (ROS) and nitrogen (RNS), exceed the strategy of antioxidant …

Guarana (Paullinia cupana) Extract Protects Caenorhabditis elegans Models for Alzheimer Disease and Huntington Disease through Activation of Antioxidant and …

PF Boasquívis, GMM Silva, FA Paiva… - Oxidative medicine …, 2018 - Wiley Online Library
Guarana (Paullinia cupana) is largely consumed in Brazil in high energy drinks and dietary
supplements because of its stimulant activity on the central nervous system. Although …