Genomic imprinting, the monoallelic and parent-of-origin-dependent expression of a subset
of genes, is required for normal development, and its disruption leads to human disease …

DNA methylation (DNAme) and histone post-translational modifications (PTMs) have
important roles in transcriptional regulation. Although many reports have characterized the …

The idea that epigenetic determinants such as DNA methylation, histone modifications or
RNA can be passed to the next generation through meiotic products (gametes) is long …

The germline mutation rate has been extensively studied and has been found to vary greatly
between species, but much less is known about the somatic mutation rate in multicellular …

DNA methylation has a profound impact on genome stability, transcription and development.
Although enzymes that catalyse DNA methylation have been well characterized, those that …

Retrotransposons have generated about 40% of the human genome. This review examines
the strategies the cell has evolved to coexist with these genomic “parasites”, focussing on …

DNA methylation is among the best studied epigenetic modifications and is essential to
mammalian development. Although the methylation status of most CpG dinucleotides in the …

In the mammalian genome, DNA methylation is an epigenetic mechanism involving the
transfer of a methyl group onto the C5 position of the cytosine to form 5-methylcytosine. DNA …

Methylation of cytosines in the mammalian genome represents a key epigenetic modification
and is dynamically regulated during development. Compelling evidence now suggests that …

DNA methylation is frequently described as a'silencing'epigenetic mark, and indeed this
function of 5-methylcytosine was originally proposed in the 1970s. Now, thanks to improved …