Colorectal cancer (CRC) represents the second leading cause of cancer-related deaths
worldwide. The pathogenesis of CRC is a complex multistep process. Among other factors …

Abstract NF-E2-related factor 2 (Nrf2) protein is a basic-region leucine zipper transcription
factor that defends against endogenous or exogenous stressors. By inducing several …

Background The global burden of sepsis is estimated as 15 to 19 million cases annually,
with a mortality rate approaching 60% in low-income countries. Methods In this retrospective …

Inflammation as a second line of defense of innate immunity plays a crucial role in
eliminating invading pathogens (bacteria, viruses, fungi as well as other parasites). The …

Most vertebrates can synthesize vitamin C with synthesis increasing during stress. Humans,
however, have lost the ability to synthesize vitamin C. Vitamin C is an important anti-oxidant …

Sepsis is a devastating disease that carries an enormous toll in terms of human suffering
and lives lost. Over 100 novel pharmacologic agents that targeted specific molecules or …

The present study aimed to investigate the anti‑ferroptosis effects of the HMGB1 inhibitor
glycyrrhizin (GLY). The present study used a cell and animal model of acute liver failure …

The Nuclear factor erythroid 2-related factor 2 (Nrf2) is a key transcription factor regulating a
wide array of genes for antioxidant and detoxification enzymes in response to oxidative and …

Sepsis, a life threating syndrome characterized by organ failure after infection, is the most
common cause of death in hospitalized patients. The treatment of sepsis is generally …

Although anti-inflammatory effects of astaxanthin (ASTX) have been suggested, the
underlying mechanisms have not been fully understood. Particularly, the modulatory action …