Metabolic disorders, particularly aberrations in lipid homeostasis, such as obesity, type 2
diabetes mellitus, and hypertriglyceridemia often manifest together as the metabolic …

The regulation of food intake in fish is a complex process carried out through several
different mechanisms in the central nervous system (CNS) with hypothalamus being the …

The underlying cell types mediating predisposition to obesity remain largely obscure. Here,
we integrated recently published single-cell RNA-sequencing (scRNA-seq) data from 727 …

Hypothalamic endoplasmic reticulum (ER) stress is a key mechanism leading to obesity.
Here, we demonstrate that ceramides induce lipotoxicity and hypothalamic ER stress …

Ceramide synthases (CerS) are key enzymes in the lipid metabolism of eukaryotic cells.
Their products, ceramides (Cer), are components of cellular membranes but also mediate …

Evidence obtained in recent years in a few species, especially rainbow trout, supports the
presence in fish of nutrient sensing mechanisms. Glucosensing capacity is present in central …

Compelling evidence has shown that, besides its putative effect on the regulation of the
gonadal axis, estradiol (E2) exerts a dichotomic effect on the hypothalamus to regulate food …

This review covers the current knowledge on the regulation of the somatic growth axis and
its interaction with metabolism and feeding regulation. The main endocrine and …

Energy-dense food alters dopaminergic (DA) transmission in the mesocorticolimbic (MCL)
system and can promote reward dysfunctions, compulsive feeding, and weight gain. Yet the …

Weight loss is often followed by weight regain. Characterizing endocrine alterations
accompanying weight reduction and regain may disentangle the complex biology of weight …