Taxanes in cancer treatment: Activity, chemoresistance and its overcoming
Since 1984, when paclitaxel was approved by the FDA for the treatment of advanced
ovarian carcinoma, taxanes have been widely used as microtubule-targeting antitumor …
ovarian carcinoma, taxanes have been widely used as microtubule-targeting antitumor …
Long non-coding RNAs in the doxorubicin resistance of cancer cells
S Ashrafizaveh, M Ashrafizadeh, A Zarrabi… - Cancer Letters, 2021 - Elsevier
Chemotherapy is the main treatment used for cancer patients failing surgery. Doxorubicin
(DOX) is a well-known chemotherapeutic agent capable of suppressing proliferation in …
(DOX) is a well-known chemotherapeutic agent capable of suppressing proliferation in …
[HTML][HTML] Exosomes as new generation vehicles for drug delivery: biomedical applications and future perspectives
A Rajput, A Varshney, R Bajaj, V Pokharkar - Molecules, 2022 - mdpi.com
Currently, particular interest among the scientific community is focused on exploring the use
of exosomes for several pharmaceutical and biomedical applications. This is due to the …
of exosomes for several pharmaceutical and biomedical applications. This is due to the …
Berberine-loaded M2 macrophage-derived exosomes for spinal cord injury therapy
ZS Gao, CJ Zhang, N Xia, H Tian, DY Li, JQ Lin, XF Mei… - Acta biomaterialia, 2021 - Elsevier
Spinal cord injury (SCI) causes immune activation of resident macrophages/microglia.
Activated macrophages/microglia have two different phenotypes, the pro-inflammatory …
Activated macrophages/microglia have two different phenotypes, the pro-inflammatory …
[HTML][HTML] Exosomes engineering and their roles as therapy delivery tools, therapeutic targets, and biomarkers
N Kučuk, M Primožič, Ž Knez, M Leitgeb - International journal of …, 2021 - mdpi.com
Exosomes are becoming increasingly important therapeutic biomaterials for use in a variety
of therapeutic applications due to their unique characteristics, especially due to the …
of therapeutic applications due to their unique characteristics, especially due to the …
Engineered extracellular vesicles as intelligent nanosystems for next-generation nanomedicine
Extracellular vesicles (EVs), as natural carriers of bioactive cargo, have a unique
micro/nanostructure, bioactive composition, and characteristic morphology, as well as …
micro/nanostructure, bioactive composition, and characteristic morphology, as well as …
Hybrid membrane-coated biomimetic nanoparticles (HM@ BNPs): a multifunctional nanomaterial for biomedical applications
Y Zhao, A Li, L Jiang, Y Gu, J Liu - Biomacromolecules, 2021 - ACS Publications
The application of nanoparticles in the diagnosis and treatment of diseases has undergone
different developmental stages, but phagocytosis and nonspecific distribution have been the …
different developmental stages, but phagocytosis and nonspecific distribution have been the …
[HTML][HTML] Tumor-targeted exosomes for delivery of anticancer drugs
Exosomes are small phospholipid bilayer vesicles that are naturally produced by all living
cells, both prokaryotes and eukaryotes. The exosomes due to their unique size, reduced …
cells, both prokaryotes and eukaryotes. The exosomes due to their unique size, reduced …
[HTML][HTML] Delivery of functional exogenous proteins by plant-derived vesicles to human cells in vitro
L Garaeva, R Kamyshinsky, Y Kil, E Varfolomeeva… - Scientific reports, 2021 - nature.com
Plant-derived extracellular vesicles (EVs) gain more and more attention as promising
carriers of exogenous bioactive molecules to the human cells. Derived from various edible …
carriers of exogenous bioactive molecules to the human cells. Derived from various edible …
[HTML][HTML] Optogenetic engineered umbilical cord MSC-derived exosomes for remodeling of the immune microenvironment in diabetic wounds and the promotion of …
X Zhao, L Fu, H Zou, Y He, Y Pan, L Ye… - Journal of …, 2023 - Springer
Background Angiogenesis and tissue repair in chronic non-healing diabetic wounds remain
critical clinical problems. Engineered MSC-derived exosomes have significant potential for …
critical clinical problems. Engineered MSC-derived exosomes have significant potential for …