Taxanes in cancer treatment: Activity, chemoresistance and its overcoming

L Mosca, A Ilari, F Fazi, YG Assaraf, G Colotti - Drug Resistance Updates, 2021 - Elsevier
Since 1984, when paclitaxel was approved by the FDA for the treatment of advanced
ovarian carcinoma, taxanes have been widely used as microtubule-targeting antitumor …

Long non-coding RNAs in the doxorubicin resistance of cancer cells

S Ashrafizaveh, M Ashrafizadeh, A Zarrabi… - Cancer Letters, 2021 - Elsevier
Chemotherapy is the main treatment used for cancer patients failing surgery. Doxorubicin
(DOX) is a well-known chemotherapeutic agent capable of suppressing proliferation in …

[HTML][HTML] Exosomes as new generation vehicles for drug delivery: biomedical applications and future perspectives

A Rajput, A Varshney, R Bajaj, V Pokharkar - Molecules, 2022 - mdpi.com
Currently, particular interest among the scientific community is focused on exploring the use
of exosomes for several pharmaceutical and biomedical applications. This is due to the …

Berberine-loaded M2 macrophage-derived exosomes for spinal cord injury therapy

ZS Gao, CJ Zhang, N Xia, H Tian, DY Li, JQ Lin, XF Mei… - Acta biomaterialia, 2021 - Elsevier
Spinal cord injury (SCI) causes immune activation of resident macrophages/microglia.
Activated macrophages/microglia have two different phenotypes, the pro-inflammatory …

[HTML][HTML] Exosomes engineering and their roles as therapy delivery tools, therapeutic targets, and biomarkers

N Kučuk, M Primožič, Ž Knez, M Leitgeb - International journal of …, 2021 - mdpi.com
Exosomes are becoming increasingly important therapeutic biomaterials for use in a variety
of therapeutic applications due to their unique characteristics, especially due to the …

Engineered extracellular vesicles as intelligent nanosystems for next-generation nanomedicine

Z Fan, C Jiang, Y Wang, K Wang, J Marsh… - Nanoscale …, 2022 - pubs.rsc.org
Extracellular vesicles (EVs), as natural carriers of bioactive cargo, have a unique
micro/nanostructure, bioactive composition, and characteristic morphology, as well as …

Hybrid membrane-coated biomimetic nanoparticles (HM@ BNPs): a multifunctional nanomaterial for biomedical applications

Y Zhao, A Li, L Jiang, Y Gu, J Liu - Biomacromolecules, 2021 - ACS Publications
The application of nanoparticles in the diagnosis and treatment of diseases has undergone
different developmental stages, but phagocytosis and nonspecific distribution have been the …

[HTML][HTML] Tumor-targeted exosomes for delivery of anticancer drugs

R Raguraman, D Bhavsar, D Kim, X Ren, V Sikavitsas… - Cancer letters, 2023 - Elsevier
Exosomes are small phospholipid bilayer vesicles that are naturally produced by all living
cells, both prokaryotes and eukaryotes. The exosomes due to their unique size, reduced …

[HTML][HTML] Delivery of functional exogenous proteins by plant-derived vesicles to human cells in vitro

L Garaeva, R Kamyshinsky, Y Kil, E Varfolomeeva… - Scientific reports, 2021 - nature.com
Plant-derived extracellular vesicles (EVs) gain more and more attention as promising
carriers of exogenous bioactive molecules to the human cells. Derived from various edible …

[HTML][HTML] Optogenetic engineered umbilical cord MSC-derived exosomes for remodeling of the immune microenvironment in diabetic wounds and the promotion of …

X Zhao, L Fu, H Zou, Y He, Y Pan, L Ye… - Journal of …, 2023 - Springer
Background Angiogenesis and tissue repair in chronic non-healing diabetic wounds remain
critical clinical problems. Engineered MSC-derived exosomes have significant potential for …