In recent years, tumor immunotherapy has made significant progress. However, tumor
immunotherapy, particularly immune checkpoint inhibitors (eg, PD-1/PD-L1 inhibitors) …

As resident macrophages of the central nervous system (CNS), microglia are associated
with diverse functions essential to the developing and adult brain during homeostasis and …

The factors driving therapy resistance in diffuse glioma remain poorly understood. To identify
treatment-associated cellular and genetic changes, we analyzed RNA and/or DNA …

Myeloid cells are the most abundant immune components of the tumour microenvironment,
where they have a variety of functions, ranging from immunosuppressive to …

In the past decade, single-cell technologies have proliferated and improved from their
technically challenging beginnings to become common laboratory methods capable of …

Brain macrophages include microglia in the parenchyma, border-associated macrophages
in the meningeal-choroid plexus-perivascular space, and monocyte-derived macrophages …

Glioblastomas are aggressive primary brain tumors with an inherent resistance to T cell-
centric immunotherapy due to their low mutational burden and immunosuppressive tumor …

Glioblastoma multiforme (GBM) is the most common and lethal brain tumor characterized by
a strongly immunosuppressive tumor microenvironment (TME) that represents a barrier also …

Background Ischemic stroke is a medical emergency that primarily affects the elderly. A
complex immune response in the post-stroke brain constitutes a key component of stroke …

Simple Summary Patients with glioblastoma—the most frequent and malignant primary brain
tumor—have a poor prognosis with a median survival of less than 15 months. Despite …